Effects of androgen deprivation therapy on pain perception, quality of life, and depression in men with prostate cancer Journal Article

Authors: Gagliano-Jucá, T.; Travison, T. G.; Nguyen, P. L.; Kantoff, P. W.; Taplin, M. E.; Kibel, A. S.; Manley, R.; Hally, K.; Bearup, R.; Beleva, Y. M.; Huang, G.; Edwards, R. R.; Basaria, S.
Article Title: Effects of androgen deprivation therapy on pain perception, quality of life, and depression in men with prostate cancer
Abstract: Context: Previous animal and human research suggests that testosterone has antinociceptive properties. Castration in male rodents increases pain perception which is reversed by testosterone replacement. Pain perception also improves in hypogonadal men with testosterone therapy. However, it remains unclear whether androgen deprivation therapy (ADT) in men with prostate cancer (PCa) is associated with an increase in pain perception. Objectives: To evaluate the effects of ADT on pain perception, depression and quality of life (QOL) in men with PCa. Methods: Thirty-seven men with PCa about to undergo ADT with leuprolide acetate (ADT group) were followed prospectively for six months to evaluate changes in clinical and experimental pain. Forty men who had previously undergone prostatectomy for localized PCa and were in remission served as controls (non-ADT group). All participants were eugonadal at study entry. Primary outcomes were changes in clinical pain (assessed with Brief Pain Inventory questionnaire) and experimental pain (assessed with quantitative sensory testing). Secondary outcomes included evaluation of depression, anxiety levels, and quality of life. Results: Serum testosterone levels significantly decreased in the ADT group but remained unchanged in the non-ADT group. There were no significant changes in pain thresholds, ratings, or other responses to quantitative sensory tests over the 6-month course of the study. Clinical pain did not differ between the two groups, and no changes from baseline were observed in either group. Men undergoing ADT did experience worsening of depression (0.93; 95% CI = 0.04–1.82; P = 0.042) and QOL related to physical role limitation (−18.28; 95% CI = −30.18 to −6.37; P = 0.003). Conclusion: ADT in men with PCa is associated with worsening of depression scores and QOL but is not associated with changes in clinical pain or pain sensitivity. © 2017 American Academy of Hospice and Palliative Medicine
Keywords: quality of life; prostate cancer; depression; testosterone; pain perception; gnrh agonists; pain tolerance; quantitative sensory testing
Journal Title: Journal of Pain and Symptom Management
Volume: 55
Issue: 2
ISSN: 0885-3924
Publisher: Elsevier Inc.  
Date Published: 2018-02-01
Start Page: 307
End Page: 317.e1
Language: English
DOI: 10.1016/j.jpainsymman.2017.09.017
PROVIDER: scopus
PMCID: PMC5794536
PUBMED: 28941963
Notes: Article -- Export Date: 3 December 2018 -- Source: Scopus
Altmetric Score
MSK Authors
  1. Philip Wayne Kantoff
    62 Kantoff