SIRT2-mediated inactivation of p73 is required for glioblastoma tumorigenicity Journal Article
| Authors: | Funato, K.; Hayashi, T.; Echizen, K.; Negishi, L.; Shimizu, N.; Koyama-Nasu, R.; Nasu-Nishimura, Y.; Morishita, Y.; Tabar, V.; Todo, T.; Ino, Y.; Mukasa, A.; Saito, N.; Akiyama, T. |
| Article Title: | SIRT2-mediated inactivation of p73 is required for glioblastoma tumorigenicity |
| Abstract: | Glioblastoma is one of the most aggressive forms of cancers and has a poor prognosis. Genomewide analyses have revealed that a set of core signaling pathways, the p53, RB, and RTK pathways, are commonly deregulated in glioblastomas. However, the molecular mechanisms underlying the tumorigenicity of glioblastoma are not fully understood. Here, we show that the lysine deacetylase SIRT2 is required for the proliferation and tumorigenicity of glioblastoma cells, including glioblastoma stem cells. Furthermore, we demonstrate that SIRT2 regulates p73 transcriptional activity by deacetylation of its C-terminal lysine residues. Our results suggest that SIRT2-mediated inactivation of p73 is critical for the proliferation and tumorigenicity of glioblastoma cells and that SIRT2 may be a promising molecular target for the therapy of glioblastoma. © 2018 The Authors |
| Keywords: | controlled study; human tissue; promoter region; nonhuman; animal cell; mouse; animal tissue; apoptosis; carboxy terminal sequence; oligodendrocyte transcription factor 2; animal experiment; animal model; caspase 3; enzyme activation; carcinogenesis; oncogene; dna; glioblastoma; carcinogenicity; gene inactivation; loss of function mutation; transcription factor sox2; short hairpin rna; protein patched 1; lysine; deacetylation; puma protein; transcription factor ezh2; cancer stem cells; caspase 7; liquid chromatography-mass spectrometry; protein acetylation; protein noxa; ectopic expression; p73; growth arrest and dna damage inducible protein 45; alpha tubulin; gene knockdown; human; priority journal; article; sirt2; sirtuin 2; t cell acute lymphocytic leukemia protein 1; tumor protein p73; ehmt1 gene; ptpro gene |
| Journal Title: | EMBO Reports |
| Volume: | 19 |
| Issue: | 11 |
| ISSN: | 1469-221X |
| Publisher: | Wiley Blackwell |
| Date Published: | 2018-11-01 |
| Start Page: | e45587 |
| Language: | English |
| DOI: | 10.15252/embr.201745587 |
| PUBMED: | 30213795 |
| PROVIDER: | scopus |
| PMCID: | PMC6216266 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 December 2018 -- Source: Scopus |
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