Activating p53 and inhibiting superenhancers to cure leukemia Journal Article
| Authors: | Ball, B.; Abdel-Wahab, O. |
| Article Title: | Activating p53 and inhibiting superenhancers to cure leukemia |
| Abstract: | In a recent study, Minzel and colleagues identified a novel series of molecules that inhibit casein kinase 1α (CK1α), CDK7, and CDK9, resulting in p53 activation and preferential inhibition of superenhancer (SE)-driven transcription. This study demonstrates a highly effective therapeutic strategy combining p53 activation with suppression of SEs to promote the cooperative killing of leukemic cells. © 2018 Elsevier Ltd |
| Keywords: | p53; myelodysplastic syndromes; acute myeloid leukemia; cdk7; cdk9; casein kinase 1a |
| Journal Title: | Trends in Pharmacological Sciences |
| Volume: | 39 |
| Issue: | 12 |
| ISSN: | 0165-6147 |
| Publisher: | Cell Press |
| Date Published: | 2018-12-01 |
| Start Page: | 1002 |
| End Page: | 1004 |
| Language: | English |
| DOI: | 10.1016/j.tips.2018.10.009 |
| PUBMED: | 30454768 |
| PROVIDER: | scopus |
| PMCID: | PMC6614867 |
| DOI/URL: | |
| Notes: | Short Survey -- Export Date: 3 December 2018 -- Source: Scopus |
