Current status and future perspectives on neoadjuvant therapy in lung cancer Journal Article

  


Authors: Blumenthal, G. M.; Bunn, P. A. Jr; Chaft, J. E.; McCoach, C. E.; Perez, E. A.; Scagliotti, G. V.; Carbone, D. P.; Aerts, H. J. W. L.; Aisner, D. L.; Bergh, J.; Berry, D. A.; Jarkowski, A.; Botwood, N.; Cross, D. A. E.; Diehn, M.; Drezner, N. L.; Doebele, R. C.; Blakely, C. M.; Eberhardt, W. E. E.; Felip, E.; Gianni, L.; Keller, S. P.; Leavey, P. J.; Malik, S.; Pignatti, F.; Prowell, T. M.; Redman, M. W.; Rizvi, N. A.; Rosell, R.; Rusch, V.; de Ruysscher, D.; Schwartz, L. H.; Sridhara, R.; Stahel, R. A.; Swisher, S.; Taube, J. M.; Travis, W. D.; Keegan, P.; Wiens, J. R.; Wistuba, I. I.; Wynes, M. W.; Hirsch, F. R.; Kris, M. G.
Article Title: Current status and future perspectives on neoadjuvant therapy in lung cancer
Abstract: This Review Article provides a multi-stakeholder view on the current status of neoadjuvant therapy in lung cancer. Given the success of oncogene-targeted therapy and immunotherapy for patients with advanced lung cancer, there is a renewed interest in studying these agents in earlier disease settings with the opportunity to have an even greater impact on patient outcomes. There are unique opportunities and challenges with the neoadjuvant approach to drug development. To achieve more rapid knowledge turns, study designs, endpoints, and definitions of pathologic response should be standardized and harmonized. Continued dialogue with all stakeholders will be critical to design and test novel induction strategies, which could expedite drug development for patients with early lung cancer who are at high risk for metastatic recurrence. © 2018
Keywords: neoadjuvant therapy; induction chemotherapy; preoperative therapy; pathologic response; resectable lung cancer
Journal Title: Journal of Thoracic Oncology
Volume: 13
Issue: 12
ISSN: 1556-0864
Publisher: Elsevier Inc.  
Date Published: 2018-12-01
Start Page: 1818
End Page: 1831
Language: English
DOI: 10.1016/j.jtho.2018.09.017
PUBMED: 30268698
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85056748537&doi=10.1016%2fj.jtho.2018.09.017&partnerID=40&md5=685f98baffa7cafa3cc9d0e9f458376c
Notes: Review -- Export Date: 3 December 2018 -- Source: Scopus
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MSK Authors
  1. Valerie W Rusch
    864 Rusch
  2. Jamie Erin Chaft
    289 Chaft
  3. William D Travis
    743 Travis
  4. Mark Kris
    869 Kris
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