Brain metastases in patients with low-grade endometrial carcinoma Journal Article


Authors: Cybulska, P.; Stasenko, M.; Alter, R.; Makker, V.; Cadoo, K. A.; Sonoda, Y.; Abu-Rustum, N. R.; Mueller, J. J.; Leitao, M. M. Jr
Article Title: Brain metastases in patients with low-grade endometrial carcinoma
Abstract: Objective: To report characteristics of patients with low-grade endometrioid endometrial carcinoma (EC) who develop brain metastases. Methods: We retrospectively identified all patients treated at our institution for FIGO grades 1/2 EC from 1/2000–12/2016, who developed brain metastases. Electronic medical records were reviewed, data abstracted. Overall survival (OS) was determined from time of brain metastases to death or last follow-up. Appropriate statistical tests were used. Results: Of 3052 patients, 23 (9, grade 1; 14, grade 2) developed brain metastases (incidence = 0.75%). Presentation at initial diagnosis: median age = 61.3 years (range, 41–81); median BMI = 29.8 kg/m2 (range, 20.3–42.6 kg/m2); distribution by stage: I, 15/23 (65%); II, 2/23 (8.7%); III, 3/23 (13.0%); IV, 3 (13.0%). None showed clinical evidence of brain metastases at presentation. Median time to diagnosis of brain metastases = 29.7 months (range, 6–145); median age = 64.6 years (range, 47.5–86.5). Brain metastases were the first, isolated site of recurrence in 2/23 (9%). All presented with neurological symptoms. Six (26%) had solitary brain lesions. Seventeen (74%) received treatment; 6 (28%), supportive care only. Median OS for patients receiving any treatment = 5.8 months (95% CI, 1.6–10.0), versus 2.4 months (95% CI, 1.5–3.3; p =.04) for best supportive care. Conclusion: Brain metastases in low-grade EC is rare, prognosis generally poor. Compared to supportive care only, any treatment results in more favorable outcomes. © 2018 The Authors
Keywords: endometrial carcinoma; brain metastases; low-grade endometrial carcinoma
Journal Title: Gynecologic Oncology Reports
Volume: 26
ISSN: 2352-5789
Publisher: Elsevier B.V.  
Date Published: 2018-11-01
Start Page: 87
End Page: 90
Language: English
DOI: 10.1016/j.gore.2018.10.010
PROVIDER: scopus
PMCID: PMC6223185
PUBMED: 30426061
DOI/URL:
Notes: Export Date: 3 December 2018 -- Source: Scopus
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MSK Authors
  1. Vicky Makker
    76 Makker
  2. Yukio Sonoda
    286 Sonoda
  3. Mario Leitao
    307 Leitao
  4. Karen Anne Cadoo
    29 Cadoo
  5. Jennifer Jean Mueller
    23 Mueller
  6. Raanan Yehuda Alter
    1 Alter