Brain metastases in patients with low-grade endometrial carcinoma Journal Article
| Authors: | Cybulska, P.; Stasenko, M.; Alter, R.; Makker, V.; Cadoo, K. A.; Sonoda, Y.; Abu-Rustum, N. R.; Mueller, J. J.; Leitao, M. M. Jr |
| Article Title: | Brain metastases in patients with low-grade endometrial carcinoma |
| Abstract: | Objective: To report characteristics of patients with low-grade endometrioid endometrial carcinoma (EC) who develop brain metastases. Methods: We retrospectively identified all patients treated at our institution for FIGO grades 1/2 EC from 1/2000–12/2016, who developed brain metastases. Electronic medical records were reviewed, data abstracted. Overall survival (OS) was determined from time of brain metastases to death or last follow-up. Appropriate statistical tests were used. Results: Of 3052 patients, 23 (9, grade 1; 14, grade 2) developed brain metastases (incidence = 0.75%). Presentation at initial diagnosis: median age = 61.3 years (range, 41–81); median BMI = 29.8 kg/m2 (range, 20.3–42.6 kg/m2); distribution by stage: I, 15/23 (65%); II, 2/23 (8.7%); III, 3/23 (13.0%); IV, 3 (13.0%). None showed clinical evidence of brain metastases at presentation. Median time to diagnosis of brain metastases = 29.7 months (range, 6–145); median age = 64.6 years (range, 47.5–86.5). Brain metastases were the first, isolated site of recurrence in 2/23 (9%). All presented with neurological symptoms. Six (26%) had solitary brain lesions. Seventeen (74%) received treatment; 6 (28%), supportive care only. Median OS for patients receiving any treatment = 5.8 months (95% CI, 1.6–10.0), versus 2.4 months (95% CI, 1.5–3.3; p =.04) for best supportive care. Conclusion: Brain metastases in low-grade EC is rare, prognosis generally poor. Compared to supportive care only, any treatment results in more favorable outcomes. © 2018 The Authors |
| Keywords: | endometrial carcinoma; brain metastases; low-grade endometrial carcinoma |
| Journal Title: | Gynecologic Oncology Reports |
| Volume: | 26 |
| ISSN: | 2352-5789 |
| Publisher: | Elsevier B.V. |
| Date Published: | 2018-11-01 |
| Start Page: | 87 |
| End Page: | 90 |
| Language: | English |
| DOI: | 10.1016/j.gore.2018.10.010 |
| PROVIDER: | scopus |
| PMCID: | PMC6223185 |
| PUBMED: | 30426061 |
| DOI/URL: | |
| Notes: | Export Date: 3 December 2018 -- Source: Scopus |
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