ERBBal remedies: Combination therapy for EGFR-mutant lung cancers Journal Article


Authors: Fan, P. D.; Yu, H. A.
Article Title: ERBBal remedies: Combination therapy for EGFR-mutant lung cancers
Abstract: Multiple members of the ERBB/HER family of the receptor tyrosine kinases have been implicated in mediating acquired resistance to EGFR inhibitors that are used to treat EGFR-mutant lung cancers. New single agents and combination therapies targeting the ERBB/HER family members are being investigated to either prevent or overcome the emergence of acquired resistance. © 2018 American Association for Cancer Research.
Keywords: cancer survival; treatment response; unclassified drug; gene mutation; exon; gene deletion; erlotinib; cancer combination chemotherapy; drug withdrawal; monotherapy; nonhuman; low drug dose; progression free survival; enzyme inhibition; gene amplification; protein degradation; protein targeting; epidermal growth factor receptor; epidermal growth factor receptor 2; genetic association; lung cancer; enzyme activation; in vitro study; tumor xenograft; enzyme activity; protein tyrosine kinase; drug design; cetuximab; phosphatidylinositol 3 kinase; oncogene; gefitinib; gene fusion; tumor promotion; feedback system; egfr gene; tumor growth; trastuzumab; epidermal growth factor receptor 3; endocytosis; protein ret; cell aging; b raf kinase; primary health care; scatter factor receptor; braf gene; non small cell lung cancer; phase 1 clinical trial (topic); drug intermittent therapy; protein axl; pi3k/akt signaling; ret gene; met gene; afatinib; alk gene; enzyme reactivation; human; priority journal; article; necitumumab; osimertinib; pc-9/r cell line
Journal Title: Clinical Cancer Research
Volume: 24
Issue: 22
ISSN: 1078-0432
Publisher: American Association for Cancer Research  
Date Published: 2018-11-15
Start Page: 5499
End Page: 5501
Language: English
DOI: 10.1158/1078-0432.ccr-18-2179
PUBMED: 30135146
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 3 December 2018 -- Source: Scopus
Altmetric Score
MSK Authors
  1. Helena Alexandra Yu
    88 Yu
  2. Pang-Dian Fan
    10 Fan