ERBBal remedies: Combination therapy for EGFR-mutant lung cancers Journal Article
| Authors: | Fan, P. D.; Yu, H. A. |
| Article Title: | ERBBal remedies: Combination therapy for EGFR-mutant lung cancers |
| Abstract: | Multiple members of the ERBB/HER family of the receptor tyrosine kinases have been implicated in mediating acquired resistance to EGFR inhibitors that are used to treat EGFR-mutant lung cancers. New single agents and combination therapies targeting the ERBB/HER family members are being investigated to either prevent or overcome the emergence of acquired resistance. © 2018 American Association for Cancer Research. |
| Keywords: | cancer survival; treatment response; unclassified drug; gene mutation; exon; gene deletion; erlotinib; cancer combination chemotherapy; drug withdrawal; monotherapy; nonhuman; low drug dose; progression free survival; enzyme inhibition; gene amplification; protein degradation; protein targeting; epidermal growth factor receptor; epidermal growth factor receptor 2; genetic association; lung cancer; enzyme activation; in vitro study; tumor xenograft; enzyme activity; protein tyrosine kinase; drug design; cetuximab; phosphatidylinositol 3 kinase; oncogene; gefitinib; gene fusion; tumor promotion; feedback system; egfr gene; tumor growth; trastuzumab; epidermal growth factor receptor 3; endocytosis; protein ret; cell aging; b raf kinase; primary health care; scatter factor receptor; braf gene; non small cell lung cancer; phase 1 clinical trial (topic); drug intermittent therapy; protein axl; pi3k/akt signaling; ret gene; met gene; afatinib; alk gene; enzyme reactivation; human; priority journal; article; necitumumab; osimertinib; pc-9/r cell line |
| Journal Title: | Clinical Cancer Research |
| Volume: | 24 |
| Issue: | 22 |
| ISSN: | 1078-0432 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2018-11-15 |
| Start Page: | 5499 |
| End Page: | 5501 |
| Language: | English |
| DOI: | 10.1158/1078-0432.ccr-18-2179 |
| PUBMED: | 30135146 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 December 2018 -- Source: Scopus |
