Anti-idiotypic monoclonal antibody cancer vaccines Journal Article
| Author: | Chapman, P. B. |
| Article Title: | Anti-idiotypic monoclonal antibody cancer vaccines |
| Abstract: | Anti-idiotypic monoclonal antibodies (MAb) can mimic both protein and non-protein in antigenic epitopes. In animal models, and now in patients, it is possible to induce immune responses against tumor antigens using anti-idiotypic MAb vaccines. While it is not clear how the efficacy of anti-idiotypic MAb vaccines compares with the efficacy of vaccines constructed from antigen, there are two situations where anti-idiotypic vaccines have potential advantages: (1) when the antigen is not readily available in sufficient quantities or purity, and (2) when the antigen is a non-protein. Clinical trials are underway using anti-idiotypic MAb vaccines in both of these situations. |
| Keywords: | mice; melanoma; immunity; vaccine; induction; ganglioside; tumor-associated antigen; immune-response; mimicry; molecular mimicry; antiidiotypic antibody; cancer; t-cell clones; gd3; internal image; anti-idiotypic antibody |
| Journal Title: | Seminars in Cancer Biology |
| Volume: | 6 |
| Issue: | 6 |
| ISSN: | 1044-579X |
| Publisher: | Academic Press Inc., Elsevier Science |
| Date Published: | 1995-12-01 |
| Start Page: | 367 |
| End Page: | 374 |
| Language: | English |
| ACCESSION: | WOS:A1995TV11700007 |
| DOI: | 10.1016/1044-579x(95)90006-3 |
| PROVIDER: | wos |
| PUBMED: | 8938275 |
| Notes: | Article -- Source: Wos |
