Paclitaxel (Taxol) and docetaxel (Taxotere): Active chemotherapeutic agents in lung cancer Conference Paper


Authors: Francis, P. A.; Kris, M. G.; Rigas, J. R.; Grant, S. C.; Miller, V. A.
Title: Paclitaxel (Taxol) and docetaxel (Taxotere): Active chemotherapeutic agents in lung cancer
Conference Title: 4th Perugia International Cancer Conference
Abstract: Paclitaxel (Taxol(R)), the prototype of a new class of plant-derived antineoplastic compounds, is a natural product isolated from the Pacific yew. Docetaxel (Taxotere(R)) is a hemisynthetic product derived from the European yew. These-agents share a unique mechanism of cytotoxic action by promoting assembly of microtubules and rendering the microtubules resistant to depolymerization. In vitro studies suggest a possible role for radiation sensitization. In Phase I trials, the dose-limiting toxicity was neutropenia for both agents. Other toxicities include infusion-related hypersensitivity reactions, alopecia, neurotoxicity, mucositis, diarrhoea and myalgias. To prevent infusion-related reactions, routine premedication is recommended. Noncumulative cardiac toxicity has been observed with paclitaxel. Fluid retention and rash have been reported with docetaxel. In Phase II studies of paclitaxel in advanced non-small cell lung cancer, response rates of 21% and 24% were observed. In Phase II studies of docetaxel in similar patients, response rates ranging from 28-38% were reported, including patients previously treated with cisplatin. The most common toxicity in these studies was neutropenia. Combination studies with cisplatin and other agents are in progress. Paclitaxel and docetaxel are among the most active chemotherapeutic agents for non-small cell lung cancer patients. Their testing will dominate trials of new therapies in this disease for years to come.
Keywords: chemotherapy; lung cancer; taxoids; trial; cells; analogs; phase-i; hypersensitivity reactions; intravenous-infusion; rp-56976; nsc-628503; paclitaxel (taxol); docetaxel (taxotere)
Journal Title Lung Cancer
Volume: 12
Issue: Suppl. 1
Conference Dates: 1993 Jun 18-19
Conference Location: Perugia, Italy
ISBN: 0169-5002
Publisher: Elsevier Ireland Ltd.  
Date Published: 1995-04-01
Start Page: S163
End Page: S172
Language: English
ACCESSION: WOS:A1995RF68600018
DOI: 10.1016/0169-5002(95)00432-z
PROVIDER: wos
PUBMED: 7551925
Notes: Article; Proceedings Paper -- Perugia International Cancer Conference IV on Chemotherapy of Non-Small Cell Lung Cancer (NSCLC): Five Years Later -- JUN 18-19, 1993 -- PERUGIA, ITALY -- 1 -- Source: Wos
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  1. Stefan C Grant
    30 Grant
  2. Vincent Miller
    270 Miller
  3. Mark Kris
    870 Kris
  4. James R. Rigas
    33 Rigas
  5. Prudence A. Francis
    16 Francis