Serum troponin T Levels during treatment of early-stage breast cancer Journal Article
| Authors: | Hughes-Davies, L.; Sacks, D.; Rescigno, J.; Howard, S.; Harris, J. |
| Article Title: | Serum troponin T Levels during treatment of early-stage breast cancer |
| Abstract: | Purpose: To measure serum troponin T concentrations in patients with early-stage left breast cancer during breast-conserving radiation therapy. Troponin T has been introduced recently as a sensitive and specific marker for acute myocardial injury. Patients and Methods: We compared pretreatment and posttreatment serum troponin T values in 50 patients undergoing radiation therapy to the entire left breast following conservative surgery for stage I and II breast cancer. Results: No changes in troponin T concentrations were found after 45 to 46 Gy whole-breast irradiation. All women had undetectable or normal troponin T on the first and last day of treatment. There was no evidence of an upward trend during treatment. Conclusion: Radiation therapy to the left breast does nor affect serum cardiac troponin T levels, despite the fact that a portion of the myocardium lies within the high-dose region. This suggests that the acute effects of radiation on the myocardium are minor. Long-term evaluation of these patients is necessary to rule out the possibility of late cardiac morbidity due to accelerated atherosclerosis, This study also suggests that an elevated troponin T level during or shortly after left breast irradiation should not be attributed to treatment. (C) 1995 by American Society of Clinical Oncology. |
| Keywords: | mortality; irradiation; therapy; pericarditis; heart-disease; hodgkins-disease |
| Journal Title: | Journal of Clinical Oncology |
| Volume: | 13 |
| Issue: | 10 |
| ISSN: | 0732-183X |
| Publisher: | American Society of Clinical Oncology |
| Date Published: | 1995-10-01 |
| Start Page: | 2582 |
| End Page: | 2584 |
| Language: | English |
| ACCESSION: | WOS:A1995RZ74400016 |
| DOI: | 10.1200/jco.1995.13.10.2582 |
| PROVIDER: | wos |
| PUBMED: | 7595710 |
| Notes: | Article -- Source: Wos |
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