Cytokine treatment of inherited bone marrow failure syndromes Journal Article
| Authors: | Gillio, A. P.; Guinan, E. C. |
| Article Title: | Cytokine treatment of inherited bone marrow failure syndromes |
| Abstract: | The inherited bone marrow failure states are rare hematologic disorders which result in peripheral blood cytopenias. To date, various treatment modalities have resulted in partial and usually short-lived responses. The recent large scale production of recombinant human hematopoietic stimulating factors (cytokines) has offered a new possible treatment modality. Recent phase I-II studies indicate a significant but unpredictable proportion of these patients will respond to cytokines with an improvement in blood counts. Multilineage responses in pancytopenic patients are rare. Duration of response, effect on natural history and potential adverse effects of long-term treatment have yet to be determined. |
| Keywords: | colony-stimulating factor; progenitor cells; factor receptors; diamond-blackfan anemia; interleukin-3; aplastic-anemia; acute myelocytic-leukemia; recombinant human; congenital hypoplastic-anemia; forming; unit-megakaryocyte; fanconis anemia |
| Journal Title: | International Journal of Pediatric Hematology/Oncology |
| Volume: | 2 |
| Issue: | 2 |
| ISSN: | 1070-2903 |
| Publisher: | Harwood Acad Publ Gmbh |
| Date Published: | 1995-01-01 |
| Start Page: | 125 |
| End Page: | 133 |
| Language: | English |
| ACCESSION: | WOS:A1995RJ12900006 |
| PROVIDER: | wos |
| Notes: | Article -- Source: Wos |
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89Gillio
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