Genetic evidence in melanoma and bladder cancers that P16 and P53 function in separate pathways of tumor suppression Journal Article
| Authors: | Gruis, N. A.; Weaver-Feldhaus, J.; Liu, Q.; Frye, C.; Eeles, R.; Orlow, I.; Lacombe, L.; Ponce-Castaneda, V.; Lianes, P.; Latres, E.; Skolnick, M.; Cordon-Cardo, C.; Kamb, A. |
| Article Title: | Genetic evidence in melanoma and bladder cancers that P16 and P53 function in separate pathways of tumor suppression |
| Abstract: | The 9p21 region of human chromosome 3 is a hot spot for chromosomal aberrations in both cultured cell lines and primary tumors. This region contains a gene, P16 (also called MTS1, CDKN2 and p16(INK4)) that encodes a presumptive negative cell cycle regulator called p16. P1G is deleted or mutated at high frequency is a variety of tumor cell lines including melanoma and bladder carcinoma lines. As such, if is likely to be a tumor suppresser gene. Here we show that P1G is mutated in primary bladder carcinomas (3 of 33) and melanomas (5 of 34). These findings support studies that show, P16 mutations are not solely a product of growth, in tissue culture but rather are involved in formation of tumors in vivo Some bladder primary tumors and some bladder and melanoma tumor cell lines contain mutations is both P16 and P53 at frequencies that suggest that p53 and p16 function in different pathways, each of which is important in suppressing malignant transformation. |
| Keywords: | mutations |
| Journal Title: | American Journal of Pathology |
| Volume: | 146 |
| Issue: | 5 |
| ISSN: | 0002-9440 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 1995-05-01 |
| Start Page: | 1199 |
| End Page: | 1206 |
| Language: | English |
| ACCESSION: | WOS:A1995QX87100020 |
| PROVIDER: | wos |
| PMCID: | PMC1869278 |
| PUBMED: | 7747814 |
| Notes: | Article -- Source: Wos |
Citation Impact
MSK Authors
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612Cordon-Cardo -
247Orlow -
19Lacombe -
11Lianes -
10Latres
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