Two-year-old female with EBV-positive diffuse large B-cell lymphoma and subsequent CNS involvement with neurolymphomatosis Journal Article
| Authors: | Bjornard, K. L.; Leventaki, V.; Nichols, K. E.; Sandlund, J. T.; Prockop, S.; Ehrhardt, M. J. |
| Article Title: | Two-year-old female with EBV-positive diffuse large B-cell lymphoma and subsequent CNS involvement with neurolymphomatosis |
| Abstract: | We describe a case of Epstein-Barr virus (EBV) positive, diffuse large B-cell lymphoma in a 2-year-old female who went on to develop relapsed/refractory central nervous system (CNS) disease, manifesting as cranial nerve neurolymphomatosis. Although her atypical presentation was thought to be associated with an immune deficiency, extensive work-up was negative. Despite subsequent treatment with third-party EBV-specific cytotoxic T-lymphocytes, she died of progressive disease. This case report raises questions as to whether tailored treatment approaches should be considered for atypical presentations of pediatric lymphoma (e.g., CNS and virus-associated). © 2018 Wiley Periodicals, Inc. |
| Keywords: | pediatric; lymphoma; neurolymphomatosis; ebv |
| Journal Title: | Pediatric Blood and Cancer |
| Volume: | 65 |
| Issue: | 12 |
| ISSN: | 1545-5009 |
| Publisher: | Wiley Periodicals, Inc |
| Date Published: | 2018-12-01 |
| Start Page: | e27415 |
| Language: | English |
| DOI: | 10.1002/pbc.27415 |
| PUBMED: | 30151967 |
| PROVIDER: | scopus |
| PMCID: | PMC8244825 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 November 2018 -- Source: Scopus |
