Intrahepatic cholangiocarcinomas have histologically and immunophenotypically distinct small and large duct patterns Journal Article


Authors: Sigel, C. S.; Drill, E.; Zhou, Y.; Basturk, O.; Askan, G.; Pak, L. M.; Vakiani, E.; Wang, T.; Boerner, T.; Do, R. K. G.; Simpson, A. L.; Jarnagin, W.; Klimstra, D. S.
Article Title: Intrahepatic cholangiocarcinomas have histologically and immunophenotypically distinct small and large duct patterns
Abstract: Intrahepatic cholangiocarcinomas are histologically heterogenous. Using a cohort of 184 clinically defined, resected intrahepatic cholangiocarcinomas, we retrospectively classified the histology into 4 subtypes: large duct (LD), small duct (SD) (predominantly tubular [SD1] or predominantly anastomosing/cholangiolar, [SD2]), or indeterminate. Then, we tested the 4 subtypes for associations with risk factors, patient outcomes, histology, and immunophenotypic characteristics. SD was the most common (84%; 24% SD1 and 60% SD2) with lower proportions of LD (8%), and indeterminate (8%). Primary sclerosing cholangitis was rare (2%), but correlated with LD (P=0.005). Chronic hepatitis, frequent alcohol use, smoking, and steatosis had no histologic association. LD was associated with mucin production (P<0.001), perineural invasion (P=0.002), CA19-9 staining (P<0.001), CK7 +, CK19 +, CD56-immunophenotype (P=0.005), and negative albumin RNA in situ hybridization (P<0.001). SD was histologically nodular (P=0.019), sclerotic (P<0.001), hepatoid (P=0.042), and infiltrative at the interface with hepatocytes (P<0.001). Albumin was positive in 71% of SD and 18% of LD (P=0.0021). Most albumin positive tumors (85%) lacked extracellular mucin (P<0.001). S100P expression did not associate with subtype (P>0.05). There was no difference in disease-specific or recurrence-free survival among the subtypes. Periductal infiltration and American Joint Committee on Cancer eighth edition pT stage predicted survival by multivariable analysis accounting for gross configuration, pT stage, and histologic type. pT2 had worse outcome relative to other pT stages. Significant differences in histology and albumin expression distinguish LD from SD, but there is insufficient evidence to support further subclassification of SD. © 2018 Wolters Kluwer Health, Inc. All rights reserved.
Keywords: albumin; intrahepatic cholangiocarcinoma; periductal infiltration
Journal Title: American Journal of Surgical Pathology
Volume: 42
Issue: 10
ISSN: 0147-5185
Publisher: Lippincott Williams & Wilkins  
Date Published: 2018-10-01
Start Page: 1334
End Page: 1345
Language: English
DOI: 10.1097/pas.0000000000001118
PROVIDER: scopus
PUBMED: 30001234
DOI/URL:
Notes: Article -- Export Date: 1 November 2018 -- Source: Scopus
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MSK Authors
  1. Olca Basturk
    203 Basturk
  2. David S Klimstra
    843 Klimstra
  3. William R Jarnagin
    583 Jarnagin
  4. Kinh Gian Do
    112 Do
  5. Efsevia Vakiani
    162 Vakiani
  6. Carlie Selbo Sigel
    53 Sigel
  7. Amber L Simpson
    50 Simpson
  8. Esther Naomi Drill
    25 Drill
  9. Gokce Askan
    40 Askan
  10. Tao Wang
    5 Wang