Gastroesophageal reflux and Barrett’s esophagus: A pathway to esophageal adenocarcinoma Journal Article
| Authors: | Schlottmann, F.; Molena, D.; Patti, M. G. |
| Article Title: | Gastroesophageal reflux and Barrett’s esophagus: A pathway to esophageal adenocarcinoma |
| Abstract: | The incidence of esophageal adenocarcinoma (EAC) has increased significantly in Western countries. The rising prevalence of gastroesophageal reflux disease (GERD) and obesity has played a major role in the increasing numbers of EAC. Approximately 10–15% of patients with GERD will develop Barrett’s esophagus (BE). This metaplastic transformation is due to the chronic injury produced by repeated reflux episodes and involves genetic mutations that can lead to a malignant transformation. Ultimately, the development of EAC is characterized by the sequence BE metaplasia–dysplasia–invasive carcinoma. © 2018, Italian Society of Surgery (SIC). |
| Keywords: | metaplasia; esophageal adenocarcinoma; high-grade dysplasia; gastroesophageal reflux disease; low-grade dysplasia; barrett’s esophagus |
| Journal Title: | Updates in Surgery |
| Volume: | 70 |
| Issue: | 3 |
| ISSN: | 2038-131X |
| Publisher: | Springer - Verlag Italia |
| Date Published: | 2018-09-01 |
| Start Page: | 339 |
| End Page: | 342 |
| Language: | English |
| DOI: | 10.1007/s13304-018-0564-y |
| PROVIDER: | scopus |
| PUBMED: | 30039277 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 November 2018 -- Source: Scopus |
