Anti-PD-1/PD-L1 immunotherapy in patients with solid organ transplant, HIV or hepatitis B/C infection Journal Article

Authors: Tio, M.; Rai, R.; Ezeoke, O. M.; McQuade, J. L.; Zimmer, L.; Khoo, C.; Park, J. J.; Spain, L.; Turajlic, S.; Ardolino, L.; Yip, D.; Goldinger, S. M.; Cohen, J. V.; Millward, M.; Atkinson, V.; Kane, A. Y.; Ascierto, P. A.; Garbe, C.; Gutzmer, R.; Johnson, D. B.; Rizvi, H. A.; Joshua, A. M.; Hellmann, M. D.; Long, G. V.; Menzies, A. M.
Article Title: Anti-PD-1/PD-L1 immunotherapy in patients with solid organ transplant, HIV or hepatitis B/C infection
Abstract: Background: Anti-programmed cell death protein 1/programmed death ligand 1 (PD-1/PD-L1) immunotherapy is now routinely used to treat several cancers. Clinical trials have excluded several populations, including patients with solid organ transplant, HIV infection and hepatitis B/C infection. We examined the safety outcomes of these populations treated with anti-PD-1/PD-L1 treatment in a multicentre retrospective study. Methods: Patients from 16 centres with advanced cancer and solid organ transplant, HIV infection or hepatitis B/C infection were included. Demographic, tumour, treatment, toxicity and outcome data were recorded. Results: Forty-six patients were included for analysis, with a median age of 60 years, and the majority of patients diagnosed with melanoma (72%). Among six patients with solid organ transplants, two graft rejections occurred, with one resulting in death, whereas two patients achieved partial responses. There were four responses in 12 patients with HIV infection. In 14 patients with hepatitis B, there were three responses, and similarly, there were three responses in 14 patients with hepatitis C. There was no unexpected toxicity in any viral infection group or an increase in viral load. Conclusion: Patients with HIV or hepatitis B/C infections treated with anti-PD-1/PD-L1 immunotherapy may respond to treatment without increased toxicity. Given the risk of graft rejection in solid organ transplant patients and also the potential for response, the role of anti-PD-1/PD-L1 immunotherapy needs to be carefully considered. © 2018 Elsevier Ltd
Keywords: hepatitis b; hepatitis c; immunotherapy; hiv; pd-1; organ transplant; cancer
Journal Title: European Journal of Cancer
Volume: 104
ISSN: 0959-8049
Publisher: Elsevier Inc.  
Date Published: 2018-11-01
Start Page: 137
End Page: 144
Language: English
DOI: 10.1016/j.ejca.2018.09.017
PROVIDER: scopus
PUBMED: 30347289
Notes: Article -- Export Date: 1 November 2018 -- Source: Scopus
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MSK Authors
  1. Matthew David Hellmann
    147 Hellmann
  2. Marietta Ogochukwu Ezeoke
    4 Ezeoke
  3. Hira Abbas Rizvi
    18 Rizvi