Tumor copy number alteration burden is a pan-cancer prognostic factor associated with recurrence and death Journal Article


Authors: Hieronymus, H.; Murali, R.; Tin, A.; Yadav, K.; Abida, W.; Moller, H.; Berney, D.; Scher, H.; Carver, B.; Scardino, P.; Schultz, N.; Taylor, B.; Vickers, A.; Cuzick, J.; Sawyers, C. L.
Article Title: Tumor copy number alteration burden is a pan-cancer prognostic factor associated with recurrence and death
Abstract: The level of copy number alteration (CNA), termed CNA burden, in the tumor genome is associated with recurrence of primary prostate cancer. Whether CNA burden is associated with prostate cancer survival or outcomes in other cancers is unknown. We analyzed the CNA landscape of conservatively treated prostate cancer in a biopsy and transurethral resection cohort, reflecting an increasingly common treatment approach. We find that CNA burden is prognostic for cancer-specific death, independent of standard clinical prognosticators. More broadly, we find CNA burden is significantly associated with disease-free and overall survival in primary breast, endometrial, renal clear cell, thyroid, and colorectal cancer in TCGA cohorts. To assess clinical applicability, we validated these findings in an independent pan-cancer cohort of patients whose tumors were sequenced using a clinically-certified next generation sequencing assay (MSK-IMPACT), where prognostic value varied based on cancer type. This prognostic association was affected by incorporating tumor purity in some cohorts. Overall, CNA burden of primary and metastatic tumors is a prognostic factor, potentially modulated by sample purity and measurable by current clinical sequencing. © 2018, Hieronymus et al.
Keywords: prostate cancer; genomics; medicine; copy number alteration; cancer biology; human; human biology
Journal Title: eLife
Volume: 7
ISSN: 2050-084X
Publisher: eLife Sciences Publications Ltd.  
Date Published: 2018-09-04
Start Page: e37294
Language: English
DOI: 10.7554/eLife.37294
PUBMED: 30178746
PROVIDER: scopus
PMCID: PMC6145837
DOI/URL:
Notes: Article -- Export Date: 1 November 2018 -- Source: Scopus
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MSK Authors
  1. Charles L Sawyers
    228 Sawyers
  2. Peter T Scardino
    672 Scardino
  3. Andrew J Vickers
    894 Vickers
  4. Rajmohan Murali
    220 Murali
  5. Brett Stewart Carver
    144 Carver
  6. Howard Scher
    1133 Scher
  7. Wassim Abida
    158 Abida
  8. Barry Stephen Taylor
    238 Taylor
  9. Nikolaus D Schultz
    497 Schultz
  10. Amy Lam Ling Tin
    122 Tin