Hypersensitivity reactions: Priming practice change to reduce incidence in first-dose rituximab treatment Journal Article


Authors: Laudati, C.; Clark, C.; Knezevic, A.; Zhang, Z.; Barton-Burke, M.
Article Title: Hypersensitivity reactions: Priming practice change to reduce incidence in first-dose rituximab treatment
Abstract: BACKGROUND: Strategies to reduce hypersensitivity reaction (HSR) incidence with rituximab include premedications and slow titration. Literature is lacking on the priming method used when preparing rituximab IV lines and the potential impact on HSR incidence. OBJECTIVES: The primary objective is to evaluate HSR incidence in titrated first-dose rituximab infusions when priming IV lines with rituximab, as compared to priming with diluent. METHODS: A retrospective, comparative, descriptive study with two arms (rituximab-versus diluent-primed) was conducted. Variables were HSR incidence in relation to priming method, age, sex, diagnosis, and premedications. For patients with HSR, severity, time to onset, and infusion rate were examined. FINDINGS: HSR incidence was significantly higher in the diluent-versus the drug-primed arm. Other significant findings included higher HSR incidence in women and lower HSR incidence in patients premedicated with dexamethasone. © 2018, Oncology Nursing Society. All rights reserved.
Keywords: rituximab; hypersensitivity reaction; cytokine release syndrome; priming; iv lines
Journal Title: Clinical Journal of Oncology Nursing
Volume: 22
Issue: 4
ISSN: 1092-1095
Publisher: Oncology Nursing Society (ONS)  
Date Published: 2018-08-01
Start Page: 407
End Page: 414
Language: English
DOI: 10.1188/18.cjon.407-414
PUBMED: 30035788
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 1 November 2018 -- Source: Scopus
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MSK Authors
  1. Zhigang Zhang
    238 Zhang
  2. Caroline Elizabeth Clark
    4 Clark