An atypical parvovirus drives chronic tubulointerstitial nephropathy and kidney fibrosis Journal Article

Authors: Roediger, B.; Lee, Q.; Tikoo, S.; Cobbin, J. C. A.; Henderson, J. M.; Jormakka, M.; O'Rourke, M. B.; Padula, M. P.; Pinello, N.; Henry, M.; Wynne, M.; Santagostino, S. F.; Brayton, C. F.; Rasmussen, L.; Lisowski, L.; Tay, S. S.; Harris, D. C.; Bertram, J. F.; Dowling, J. P.; Bertolino, P.; Lai, J. H.; Wu, W.; Bachovchin, W. W.; Wong, J. J. L.; Gorrell, M. D.; Shaban, B.; Holmes, E. C.; Jolly, C. J.; Monette, S.; Weninger, W.
Article Title: An atypical parvovirus drives chronic tubulointerstitial nephropathy and kidney fibrosis
Abstract: The occurrence of a spontaneous nephropathy with intranuclear inclusions in laboratory mice has puzzled pathologists for over 4 decades, because its etiology remains elusive. The condition is more severe in immunodeficient animals, suggesting an infectious cause. Using metagenomics, we identify the causative agent as an atypical virus, termed "mouse kidney parvovirus" (MKPV), belonging to a divergent genus of Parvoviridae. MKPV was identified in animal facilities in Australia and North America, is transmitted via a fecal-oral or urinary-oral route, and is controlled by the adaptive immune system. Detailed analysis of the clinical course and histopathological features demonstrated a stepwise progression of pathology ranging from sporadic tubular inclusions to tubular degeneration and interstitial fibrosis and culminating in renal failure. In summary, we identify a widely distributed pathogen in laboratory mice and establish MKPV-induced nephropathy as a new tool for elucidating mechanisms of tubulointerstitial fibrosis that shares molecular features with chronic kidney disease in humans. Copyright © 2018 Elsevier Inc. All rights reserved.
Keywords: fibrosis; chronic kidney disease; viral metagenomics; parvovirus; parvoviridae; inclusion body nephropathy; tubulointerstitial fibrosis
Journal Title: Cell
Volume: 175
Issue: 2
ISSN: 0092-8674
Publisher: Cell Press  
Date Published: 2018-10-04
Start Page: 530
End Page: 543.e24
Language: English
DOI: 10.1016/j.cell.2018.08.013
PUBMED: 30220458
PROVIDER: scopus
Notes: Article -- Export Date: 1 November 2018 -- Source: Scopus
Altmetric Score
MSK Authors
  1. Sebastien Monette
    75 Monette