Photon irradiation for spinal chordomas and chondrosarcomas Book Section
| Authors: | Lockney, D. T.; Lockney, N. A.; Schmitt, A.; Yamada, J.; Bilsky, M.; Laufer, I. |
| Editors: | Harsh, G. R. 4th; Vaz-Guimaraes, F. |
| Article/Chapter Title: | Photon irradiation for spinal chordomas and chondrosarcomas |
| Abstract: | While surgical excision represents the primary curative modality for chondrosarcomas and chordomas, tumor-free surgical margins can be difficult or impossible to achieve in the spine without significant morbidity. Therefore, additional therapy is usually needed for durable local control. Adjuvant radiotherapy to a minimum of 60-65. Gy is recommended following incomplete resection or positive margins, though data are limited to largely retrospective series. Radiotherapy has also been given preoperatively in conjunction with a postoperative boost. The advent of intensity-modulated radiation therapy has allowed safer delivery of higher doses of radiation to spinal tumors with conventional fractionation. Perhaps more promising, however, is the emergence of stereotactic radiosurgery to deliver high-dose radiotherapy to tumors with a steep dose gradient around the spinal cord. By overcoming radioresistance typically associated with chordoma and chondrosarcoma, stereotactic radiosurgery may offer definitive local control as a surgical replacement or adjuvant. © 2018 Elsevier Inc. All rights reserved. |
| Keywords: | stereotactic radiosurgery; chondrosarcoma; chordoma; sacrum; mobile spine; image-guided radiation therapy; external beam radiation; photon irradiation |
| Book Title: | Chordomas and Chondrosarcomas of the Skull Base and Spine. 2nd ed |
| ISBN: | 978-0-12-804257-1 |
| Publisher: | Academic Press, Elsevier Inc |
| Date Published: | 2018-01-01 |
| Start Page: | 355 |
| End Page: | 362 |
| Language: | English |
| DOI: | 10.1016/b978-0-12-804257-1.00033-5 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Book Chapter: 33 -- Export Date: 1 November 2018 -- Source: Scopus |
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