Molecular investigation of breast cancer Book Section


Authors: Wilkerson, P. M.; Reis-Filho, J. S.
Editors: Benson, J. R.; Gui, G.; Tuttle, T. M.
Article/Chapter Title: Molecular investigation of breast cancer
Abstract: The categories of ER-positive and ER-negative breast cancers are heterogeneous at the molecular level; for example, multiple molecular subtypes of ER-negative breast cancer have been described (1,2,8-11), whose clinical significance remains to be determined. By contrast, ER-positive breast cancers form a continuum, with tumors at one end having a good prognosis and characterized by low histological grade, low proliferation rates, simple karyotypes, low levels of genomic instability, deletions of 16q, and recurrent mutations of PIK3CA. Tumors at the other end of the spectrum have a poor prognosis, are of high histological grade, have complex karyotypes and high levels of genetic instability, and often harbor mutations in key tumor suppressor genes (e.g., TP53) (12-17). © 2013 by Taylor & Francis Group, LLC.
Book Title: Early Breast Cancer: From Screening to Multidisciplinary Management. 3rd ed
ISBN: 9781841848860
Publisher: CRC Press  
Publication Place: Boca Raton, FL
Date Published: 2013-01-01
Start Page: 286
End Page: 304
Language: English
PROVIDER: scopus
DOI/URL:
Notes: Book Chapter: 29 -- Export Date: 1 November 2018 -- Source: Scopus