Dextromethorphan shows efficacy in experimental pain (nociception) and opioid tolerance Conference Paper
| Authors: | Elliott, K. J.; Brodsky, M.; Hynansky, A.; Foley, K. M.; Inturrisi, C. E. |
| Title: | Dextromethorphan shows efficacy in experimental pain (nociception) and opioid tolerance |
| Conference Title: | 2nd International Conference on the Varicella-Zoster Virus |
| Abstract: | The oral antitussive dextromethorphan is a clinically available N-methyl-D-aspartate receptor antagonist. Dextromethorphan has analgesic efficacy in the experimental formalin test, blocks the nociceptive activation of the immediate-early gene, c-fos proto-oncogene, and prevents and reverses the development of opiate analgesic tolerance in experimental models. These data suggest that dextromethorphan should be evaluated in a controlled clinical trial for analgesic efficacy in zoster-associated neuralgia. |
| Keywords: | controlled study; nonhuman; conference paper; mouse; pain; animal experiment; animal model; morphine; analgesia; drug tolerance; postherpetic neuralgia; nociceptors; n methyl dextro aspartic acid receptor; antitussive agent; dizocilpine; subcutaneous drug administration; narcotics; humans; male; priority journal; dextromethorphan; oncogene c fos; endogenous compound; decahydro 6 phosphonomethyl 3 isoquinolinecarboxylic acid |
| Journal Title | Neurology |
| Volume: | 45 |
| Issue: | 12 Suppl. 8 |
| Conference Dates: | 1994 Jul 7-8 |
| Conference Location: | Paris, France |
| ISBN: | 0028-3878 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 1995-12-01 |
| Start Page: | S66 |
| End Page: | S68 |
| Language: | English |
| PUBMED: | 8545027 |
| PROVIDER: | scopus |
| DOI: | 10.1212/WNL.45.12_Suppl_8.S66 |
| DOI/URL: | |
| Notes: | Conference Paper -- Export Date: 28 August 2018 -- Source: Scopus |
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