Practical applications for peripheral blood progenitor cells in the treatment of lymphomas and solid tumours Conference Paper
| Author: | Pettengell, R. |
| Title: | Practical applications for peripheral blood progenitor cells in the treatment of lymphomas and solid tumours |
| Conference Title: | 1st Meeting of the European Haematology Association (EHA) |
| Abstract: | Autologous blood progenitor cell (BPC) support is used in conjunction with high-dose chemotherapy regimens and also permits the use of increasing dose-intensity schedules of conventional cytotoxic chemotherapy. However, our understanding of the optimal BPC support to be used in these different conditions is incomplete. These difficulties result from the use of different BPC collection procedures in different centres, to different patient populations and considerable variability between patients. For such treatment to be cost effective, greater knowledge is required about the best way of achieving mobilisation, collection, storage and engraftment of BPC. The use of G-CSF in combination with chemotherapy can yield sufficient BPC at a single apheresis to achieve haematopoietic reconstitution after high-dose therapy. This was partly achieved by accurate prediction of the optimum timing of cell collection, which coincided with the early exponential increase in white blood cells (WBC) after the chemotherapy induced nadir. BPC in apheresis product or whole blood from patients primed with chemotherapy and filgrastim (G-CSF) were found to be viable for 48 hours when stored at 4°C. Patients receiving multicyclic ifosfamide, carboplatin and etoposide (ICE) chemotherapy received BPC in apheresis product or whole blood, which had been stored at 4°C, on day 3 of each treatment cycle. Such an approach allowed a 200% increase in dose intensity without any increase in toxicity or the need for supportive care. Optimal use of BPC support may increase the effectiveness of chemotherapy for the common solid tumours. |
| Keywords: | cancer chemotherapy; doxorubicin; solid tumor; conference paper; carboplatin; infection; bone marrow suppression; etoposide; cyclophosphamide; vincristine; ifosfamide; peripheral blood stem cell; lymphoma; bleomycin; ketoconazole; recombinant granulocyte colony stimulating factor; cotrimoxazole; granulocyte colony stimulating factor; intravenous drug administration; oral drug administration; g-csf; filgrastim; dose-intensity; apheresis; cytotoxic chemotherapy; human; priority journal; blood progenitor cell |
| Journal Title | Annals of Oncology |
| Volume: | 6 |
| Issue: | Suppl. 4 |
| Conference Dates: | 1994 Jun 2-5 |
| Conference Location: | Brussels, Belgium |
| ISBN: | 0923-7534 |
| Publisher: | Oxford University Press |
| Date Published: | 1995-01-01 |
| Start Page: | 9 |
| End Page: | 12 |
| Language: | English |
| DOI: | 10.1093/annonc/6.suppl_4.S9 |
| PUBMED: | 8750138 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | According to the issue's Foreword, this paper was presented at 2 satellite symposia: 1st Meeting of the European Haematology Association (EHA) on Jun 2-5 1994 in Brussels, Belgium, and the 19th Congress of the European Society of Medical Oncology (ESMO) on Nov 18-22 1994 in Lisbon, Portugal -- Conference Paper -- Export Date: 28 August 2018 -- Source: Scopus |
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