Quimioterapia a altas dosis en el cáncer de mama metastásico: Múltiples ciclos y expansión ex vivo de células progenitoras hematopoyéticas Journal Article

  


Authors: Albanell, J.; Bellmunt, J.; Solé Calvo, L. A.
Article Title: Quimioterapia a altas dosis en el cáncer de mama metastásico: Múltiples ciclos y expansión ex vivo de células progenitoras hematopoyéticas
Abstract: Purpose: To update 1) the strategy of multiple cycles of high-dose chemotherapy (HDC) in metastasic breast cancer and 2) recent advances in the hematological support of HDC. Material and methods: Review of the basis and results of multiple cycles of HDC and historical comparison with a single cycle of HDC. Review of state-of-the-art techniques for hematological support, including ex-vivo expansion and CD34+ selection of hematopoietic cells. Results: Preclinical models support the research of multiple cycles of HDC. Studies conducted at Memorial Sloan-Kettering Cancer Center establish the feasibility of this strategy. Preliminary data show equal of higher antitumoral activity than a single cycle of HDC. CD34 selection and ex-vivo expansion of progenitor cells yield a rapid hematological recovery, may widen the number of patients candidates to HDC and may facilitate the delivery of multiple cycles of HDC. Conclusions: Randomized trials may be needed to compare multiple cycles versus a single cycle of HDC. CD34+ selection and ex-vivo expansion of progenitor blood cells will facilitate multiple-cycle HDC protocols.
Keywords: hydroxyurea; review; cisplatin; fluorouracil; paclitaxel; methotrexate; carboplatin; breast cancer; cyclophosphamide; melphalan; stem cell transplantation; thiotepa; hematopoietic stem cell; granulocyte colony stimulating factor; ex-vivo expansion; high-dose chemotherapy; cd34; human; female; multiple cycles
Journal Title: Oncologia
Volume: 18
Issue: 12
ISSN: 0378-4835
Publisher: Alpe Editores S.A.  
Date Published: 1995-09-12
Start Page: 589
End Page: 602
Language: Spanish
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0029617959&partnerID=40&md5=42448de392526ff05657284483ddec9e
Notes: [High-dose chemotherapy in metastatic breast cancer: Multiple cycles and ex vivo expansion of progenitor blood cells] -- Review -- Erratum issued, see Oncologia, 1996; 19 (3): 86 -- Export Date: 28 August 2018 -- Source: Scopus