Improving outcomes in primary CNS lymphoma Journal Article

  


Authors: Graham, M. S.; DeAngelis, L. M.
Article Title: Improving outcomes in primary CNS lymphoma
Abstract: Primary central nervous system lymphoma (PCNSL) is an aggressive disease with previously poor prognosis. The advent of high-dose methotrexate-based induction regimens as well as use of consolidation therapy has greatly improved this prognosis in recent decades, but durable remission still eludes half of patients. In this review, we summarize the progress made in the treatment of PCNSL as well as the challenges that remain, with a focus on defining optimal induction and consolidation regimens, including the promise of developing biotherapies. Future studies will help delineate the best combination of existing and novel treatment strategies, with the goal of expanding the cohort of patients achieving a cure. © 2018
Keywords: cancer survival; treatment outcome; treatment response; overall survival; lenalidomide; prednisone; review; doxorubicin; cancer combination chemotherapy; primary central nervous system lymphoma; cytarabine; methotrexate; rituximab; temozolomide; cancer immunotherapy; progression free survival; etoposide; maintenance therapy; cyclophosphamide; dexamethasone; vincristine; autologous stem cell transplantation; carmustine; procarbazine; thiotepa; temsirolimus; targeted therapy; biological therapy; pemetrexed; elderly; geriatric patient; induction chemotherapy; whole brain radiotherapy; molecularly targeted therapy; consolidation chemotherapy; nivolumab; ibrutinib; buparlisib; human; priority journal; pembrolizumab; primary refractory disease
Journal Title: Best Practice and Research: Clinical Haematology
Volume: 31
Issue: 3
ISSN: 1521-6926
Publisher: Elsevier Inc.  
Date Published: 2018-09-01
Start Page: 262
End Page: 269
Language: English
DOI: 10.1016/j.beha.2018.07.006
PROVIDER: scopus
PUBMED: 30213395
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050865348&doi=10.1016%2fj.beha.2018.07.006&partnerID=40&md5=b3e6e2696a9c809a7023a84690c81abe
Notes: Review -- Export Date: 5 October 2018 -- Source: Scopus
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MSK Authors
  1. Lisa De Angelis
    576 De Angelis
  2. Maya Srikanth Graham
    22 Graham
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