Intrahepatic cholangiocarcinoma: Can imaging phenotypes predict survival and tumor genetics? Journal Article
| Authors: | Aherne, E. A.; Pak, L. M.; Goldman, D. A.; Gonen, M.; Jarnagin, W. R.; Simpson, A. L.; Do, R. K. |
| Article Title: | Intrahepatic cholangiocarcinoma: Can imaging phenotypes predict survival and tumor genetics? |
| Abstract: | Purpose: On computed tomography (CT), intrahepatic cholangiocarcinomas (ICC) are a visibly heterogeneous group of tumors. The purpose of this study was to investigate the associations between CT imaging phenotypes, patient survival, and known genetic markers. Methods: A retrospective study was performed with 66 patients with surgically resected ICC. Pre-surgical CT images of ICC were assessed by radiologists blinded to tumor genetics and patient clinical data. Associations between qualitative imaging features and overall survival (OS) and disease-free survival (DFS) were performed with Cox proportional hazards regression and visualized with Kaplan–Meier plots. Associations between radiographic features and genetic pathways (IDH1, Chromatin and RAS-MAPK) were assessed with Fisher’s Exact test and the Wilcoxon Rank sum test where appropriate and corrected for multiple comparisons within each pathway using the False Discovery Rate correction. Results: Three imaging features were significantly associated with a higher risk of death: necrosis (hazard ratio (HR) 2.95 95% CI 1.44–6.04, p = 0.029), satellite nodules (HR 3.29, 95% CI:1.35–8.02, p = 0.029), and vascular encasement (HR 2.63, 95% CI 1.28–5.41, p = 0.029). Additionally, with each increase in axial size, the risk of death increased (HR 1.14, 95% CI 1.03–1.26, p = 0.029). Similar to findings for OS, satellite nodules (HR 3.81, 95% CI 1.88–7.71, p = 0.002) and vascular encasement (HR 2.25, 95% CI 1.24–4.06, p = 0.019) were associated with increased risk of recurrence/death. No significant associations were found between radiographic features and genes in the IDH1, Chromatin or RAS-MAPK pathways (p = 0.63–84). Conclusion: This preliminary analysis of resected ICC suggests associations between CT imaging features and OS and DFS. No association was identified between imaging features and currently known genetic pathways. © 2018, Springer Science+Business Media, LLC, part of Springer Nature. |
| Keywords: | survival; cholangiocarcinoma; radiogenomics; radiomics |
| Journal Title: | Abdominal Radiology |
| Volume: | 43 |
| Issue: | 10 |
| ISSN: | 2366-004X |
| Publisher: | Springer |
| Date Published: | 2018-10-01 |
| Start Page: | 2665 |
| End Page: | 2672 |
| Language: | English |
| DOI: | 10.1007/s00261-018-1505-4 |
| PROVIDER: | scopus |
| PMCID: | PMC6113129 |
| PUBMED: | 29492607 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 5 October 2018 -- Source: Scopus |
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