Intrahepatic cholangiocarcinoma: Can imaging phenotypes predict survival and tumor genetics? Journal Article


Authors: Aherne, E. A.; Pak, L. M.; Goldman, D. A.; Gonen, M.; Jarnagin, W. R.; Simpson, A. L.; Do, R. K.
Article Title: Intrahepatic cholangiocarcinoma: Can imaging phenotypes predict survival and tumor genetics?
Abstract: Purpose: On computed tomography (CT), intrahepatic cholangiocarcinomas (ICC) are a visibly heterogeneous group of tumors. The purpose of this study was to investigate the associations between CT imaging phenotypes, patient survival, and known genetic markers. Methods: A retrospective study was performed with 66 patients with surgically resected ICC. Pre-surgical CT images of ICC were assessed by radiologists blinded to tumor genetics and patient clinical data. Associations between qualitative imaging features and overall survival (OS) and disease-free survival (DFS) were performed with Cox proportional hazards regression and visualized with Kaplan–Meier plots. Associations between radiographic features and genetic pathways (IDH1, Chromatin and RAS-MAPK) were assessed with Fisher’s Exact test and the Wilcoxon Rank sum test where appropriate and corrected for multiple comparisons within each pathway using the False Discovery Rate correction. Results: Three imaging features were significantly associated with a higher risk of death: necrosis (hazard ratio (HR) 2.95 95% CI 1.44–6.04, p = 0.029), satellite nodules (HR 3.29, 95% CI:1.35–8.02, p = 0.029), and vascular encasement (HR 2.63, 95% CI 1.28–5.41, p = 0.029). Additionally, with each increase in axial size, the risk of death increased (HR 1.14, 95% CI 1.03–1.26, p = 0.029). Similar to findings for OS, satellite nodules (HR 3.81, 95% CI 1.88–7.71, p = 0.002) and vascular encasement (HR 2.25, 95% CI 1.24–4.06, p = 0.019) were associated with increased risk of recurrence/death. No significant associations were found between radiographic features and genes in the IDH1, Chromatin or RAS-MAPK pathways (p = 0.63–84). Conclusion: This preliminary analysis of resected ICC suggests associations between CT imaging features and OS and DFS. No association was identified between imaging features and currently known genetic pathways. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.
Keywords: survival; cholangiocarcinoma; radiogenomics; radiomics
Journal Title: Abdominal Radiology
Volume: 43
Issue: 10
ISSN: 2366-004X
Publisher: Springer  
Date Published: 2018-10-01
Start Page: 2665
End Page: 2672
Language: English
DOI: 10.1007/s00261-018-1505-4
PROVIDER: scopus
PMCID: PMC6113129
PUBMED: 29492607
DOI/URL:
Notes: Article -- Export Date: 5 October 2018 -- Source: Scopus
Altmetric Score
MSK Authors
  1. Mithat Gonen
    713 Gonen
  2. William R Jarnagin
    590 Jarnagin
  3. Kinh Gian Do
    115 Do
  4. Debra Alyssa Goldman
    94 Goldman
  5. Amber L Simpson
    51 Simpson
  6. Linda Ma
    16 Ma
  7. Alanna Julianne Emily Aherne
    2 Aherne