Comparison of biliary brush biopsy and fine needle biopsy in the diagnosis of biliary strictures Journal Article


Authors: Gonzalez-Aguirre, A.; Covey, A. M.; Brown, K. T.; Brody, L. A.; Boas, F. E.; Sofocleous, C. T.; Maybody, M.; Getrajdman, G. I.; Erinjeri, J. P.
Article Title: Comparison of biliary brush biopsy and fine needle biopsy in the diagnosis of biliary strictures
Abstract: Purpose: The purpose of this study is to evaluate the accuracy of percutaneous fine needle biopsy (FNB) and brush biopsy (BB) at a cancer center. Material and methods: Retrospective analysis of all bile duct biopsies performed in Interventional Radiology between January 2000 and January 2015 was performed. FNB was performed under real-time cholangiographic guidance using a notched needle directed at the bile duct stricture. BB was performed by advancing a brush across the stricture and moving it back and forth to scrape the stricture. Biopsy results were categorized as true positive (TP), true negative (TN), false positive (FP) and false negative (FN) based on pathology reports and confirmed by surgical specimens or clinical follow-up of at least six months. Fisher’s exact test was used to compare the rate of TP in FNB and BB. Results: One-hundred and nineteen patients underwent FNB or BB. Fifteen were censored because of lack of follow-up. The remaining 104 patients underwent a total of 117 bile duct biopsies during the study period: 34 FNB and 83 BB. There were no complications in either group. In the FNB group 22/34 (64%) biopsies were TP, 4/34(12%) were TN and there were 8(24%) FN biopsies. In the BB group, 20/83 (24%) were TP, 38/83 (46%) TN and 25/83 (30%) FN biopsies. There were no FP biopsies in either group. The sensitivity of detecting malignancy by FNB was significantly higher than that by BB (73% vs 44%, p <.0005). There were no complications associated with FNB or BB. Conclusions: FNB of bile duct strictures is safe and has a higher sensitivity for detecting malignancy than BB. © 2018, © 2018 Society of Medical Innovation and Technology.
Keywords: interventional radiology; percutaneous biopsy; image-guided procedures; bile duct stricture
Journal Title: Minimally Invasive Therapy and Allied Technologies
Volume: 27
Issue: 5
ISSN: 1364-5706
Publisher: Taylor & Francis Group  
Date Published: 2018-01-01
Start Page: 278
End Page: 283
Language: English
DOI: 10.1080/13645706.2018.1427597
PROVIDER: scopus
PUBMED: 29390936
DOI/URL:
Notes: Article -- Export Date: 1 October 2018 -- Source: Scopus
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MSK Authors
  1. Anne Covey
    118 Covey
  2. Majid Maybody
    71 Maybody
  3. Lynn Brody
    93 Brody
  4. Karen T Brown
    161 Brown
  5. Franz Edward Boas
    35 Boas