Long-term follow-up of 4 patients with conjunctival amyloidosis Journal Article


Authors: Prager, A. J.; Habib, L. A.; Gambogi, T.; Busam, K. J.; Marr, B. P.
Article Title: Long-term follow-up of 4 patients with conjunctival amyloidosis
Abstract: Conjunctival amyloidosis is a rare cause of ocular inflammation, mass, and hemorrhage that can be difficult to diagnose and treat. In this case series, we describe 4 patients with a histopathological diagnosis of conjunctival amyloidosis treated at a single institution. All patients underwent surgical excision and biopsy. On histopathological examination, 3 patients had local deposition of either kappa or lambda monoclonal immunoglobulin light chains, favoring localized amyloid light-chain amyloidosis. Systemic workup to exclude rheumatologic disorders (e.g., anti-neutrophil cytoplasmic antibody and rheumatoid factors) and hematological disorders (e.g., imaging, biopsies, and serum protein electrophoresis/urine protein electrophoresis) was negative except for a positive abdominal fat biopsy in 1 patient. Patients were followed for an average of 6.1 years (range 4 months to 15 years) with stable ocular disease. © 2018 S. Karger AG, Basel.
Keywords: treatment; conjunctival amyloidosis; ocular amyloidosis
Journal Title: Ocular Oncology and Pathology
Volume: 4
Issue: 5
ISSN: 2296-4681
Publisher: Karger  
Date Published: 2018-09-01
Start Page: 313
End Page: 317
Language: English
DOI: 10.1159/000485918
PROVIDER: scopus
PMCID: PMC6167687
PUBMED: 30320104
DOI/URL:
Notes: Article -- Export Date: 1 October 2018 -- Source: Scopus
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MSK Authors
  1. Brian Marr
    112 Marr
  2. Klaus J Busam
    669 Busam
  3. Alisa Jennifer Prager
    6 Prager
  4. Larissa Ann Habib
    9 Habib
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