Control of meiotic double-strand-break formation by ATM: Local and global views Journal Article

   

Authors:	Lukaszewicz, A.; Lange, J.; Keeney, S.; Jasin, M.
Article Title:	Control of meiotic double-strand-break formation by ATM: Local and global views
Abstract:	DNA double-strand breaks (DSBs) generated by the SPO11 protein initiate meiotic recombination, an essential process for successful chromosome segregation during gametogenesis. The activity of SPO11 is controlled by multiple factors and regulatory mechanisms, such that the number of DSBs is limited and DSBs form at distinct positions in the genome and at the right time. Loss of this control can affect genome integrity or cause meiotic arrest by mechanisms that are not fully understood. Here we focus on the DSB-responsive kinase ATM and its functions in regulating meiotic DSB numbers and distribution. We review the recently discovered roles of ATM in this context, discuss their evolutionary conservation, and examine future research perspectives. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.
Keywords:	meiotic recombination; dna double-strand break; atm/tel1 kinase
Journal Title:	Cell Cycle
Volume:	17
Issue:	10
ISSN:	1538-4101
Publisher:	Taylor & Francis Inc.
Date Published:	2018-01-01
Start Page:	1155
End Page:	1172
Language:	English
DOI:	10.1080/15384101.2018.1464847
PROVIDER:	scopus
PMCID:	PMC6110601
PUBMED:	29963942
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85052195170&doi=10.1080%2f15384101.2018.1464847&partnerID=40&md5=05610d0d21458f3720f6d8f1f97aaebd
Notes:	Review -- Export Date: 1 October 2018 -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/131689