Feasibility of reirradiation of recurrent sinonasal carcinoma in the periorbital region using hypofractionated image-guided intensity-modulated radiation therapy Journal Article
| Authors: | Thiagarajan, A.; Mechalakos, J.; Lee, N. |
| Article Title: | Feasibility of reirradiation of recurrent sinonasal carcinoma in the periorbital region using hypofractionated image-guided intensity-modulated radiation therapy |
| Abstract: | Background Recurrent periorbital tumors pose management challenges because they are often unresectable and chemorefractory. Proximity to critical structures renders reirradiation difficult. With image-guided intensity-modulated radiation therapy (IG-IMRT), real-time corrections to patient setup are possible, enabling significant shrinkage of planning target volume margins and safe dose escalation with hypofractionation. Here, we present our experience with hypofractionated IG-IMRT in a patient with multiply recurrent sinonasal carcinomas in the periorbital region. Methods The patient is a 67-year-old woman with sinonasal carcinoma, treated with surgery and 2 prior courses of high-dose radiotherapy. She developed a second tumor recurrence in the right lateral orbit, which was reirradiated using hypofractionated IG-IMRT (24 Gy in 3 fractions). Results Near-complete resolution of her ocular symptoms was observed at 4 months. Progress scans demonstrated a decrease in size of the orbital lesion. Conclusion Preliminary results of reirradiation using hypofractionated IG-IMRT suggest that it is safe and effective. © 2010 Wiley Periodicals, Inc. Head Neck, 2010 Copyright © 2010 Wiley Periodicals, Inc. |
| Keywords: | aged; disease course; case report; intensity modulated radiation therapy; treatment planning; paclitaxel; cancer radiotherapy; radiation dose; methotrexate; nuclear magnetic resonance imaging; outcome assessment; positron emission tomography; recurrent cancer; carboplatin; computer assisted tomography; mucosa inflammation; weight reduction; tumor biopsy; dysphagia; feasibility study; dosimetry; radiation dose fractionation; irradiation; xerostomia; retina; therapy effect; optic nerve; diplopia; radiation dose distribution; brain stem; hypofractionation; optic chiasm; radiation dermatitis; eye pain; image-guided; repeat procedure; exophthalmos; skull; epiphora; reirradiation; paranasal sinus carcinoma; head and neck cancers; hypofractionated image guided intensity modulated radiation therapy; maxillary sinus; nose septum; periorbital region; sinonasal carcinoma |
| Journal Title: | Head & Neck |
| Volume: | 33 |
| Issue: | 9 |
| ISSN: | 1043-3074 |
| Publisher: | John Wiley & Sons, Inc. |
| Date Published: | 2011-09-01 |
| Start Page: | 1372 |
| End Page: | 1378 |
| Language: | English |
| DOI: | 10.1002/hed.21385 |
| PROVIDER: | scopus |
| PUBMED: | 20848409 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 3 October 2011" - "CODEN: HEANE" - "Source: Scopus" |
