Structural studies of vinblastine alkaloids by exciton coupled circular dichroism Journal Article
| Authors: | Dong, J. G.; Bornmann, W.; Nakanishi, K.; Berova, N. |
| Article Title: | Structural studies of vinblastine alkaloids by exciton coupled circular dichroism |
| Abstract: | SCF-CI-dipole velocity MO calculations have shown that the bisignate circular dichroic curves of vinblastine/vincristine alkaloids at ca 210 and 220-230 nm are due to exciton coupling between the indoline and indole moieties. Furthermore, a combination of X-ray crystal structure data with MM2 local energy minimization provides a convenient means for estimation of the preferred solution conformation. © 1995. |
| Keywords: | comparative study; vincristine; vinblastine; chemistry; drug derivative; magnetic resonance spectroscopy; nuclear magnetic resonance spectroscopy; models, molecular; crystallography, x-ray; chemical structure; vinca alkaloid; conformation; x ray crystallography; molecular conformation; vinca alkaloids; circular dichroism; spectrophotometry; article; vinca; absolute configuration; apocynaceae; catharanthus roseus; exciton coupling; vinblastine alkaloids |
| Journal Title: | Phytochemistry |
| Volume: | 40 |
| Issue: | 6 |
| ISSN: | 0031-9422 |
| Publisher: | Pergamon-Elsevier Science Ltd |
| Date Published: | 1995-12-01 |
| Start Page: | 1821 |
| End Page: | 1824 |
| Language: | English |
| DOI: | 10.1016/0031-9422(95)00627-j |
| PUBMED: | 8590642 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 28 August 2018 -- Source: Scopus |
