Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres Journal Article

  


Authors: Xuan, S.; Baptista, C. A.; Balas, G.; Tao, W.; Soares, V. C.; Lai, E.
Article Title: Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres
Abstract: We generated mice with a null mutation of the forebrain-restricted transcription factor BF-1 to examine its function in brain development. Heterozygous animals have an apparently normal phenotype. Homozygous null BF-1 mutants die at birth and have a dramatic reduction in the size of the cerebral hemispheres. The development of the ventral telencephalon is more severely affected than that of the dorsal telencephalon. Telencephalic neuroepithelial cells are specified in the BF-1 mutant, but their proliferation is reduced. Dorsal telencephalic neuroepithelial cells also differentiate prematurely, leading to early depletion of the progenitor population. These results suggest that BF-1 controls the morphogenesis of the telencephalon by regulating the rate of neuroepithelial cell proliferation and the timing of neuronal differentiation. © 1995.
Keywords: mutation; dna-binding proteins; nonhuman; cell proliferation; animal cell; animal; mice; cell division; mice, mutant strains; nerve tissue proteins; genotype; transcription factor; morphogenesis; cell differentiation; heterozygote; regulatory mechanism; molecular sequence data; brain; brain development; homozygote; epithelial cells; base sequence; epithelium; cerebral cortex; nerve cell differentiation; hemisphere; telencephalon; cell kinetics; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.
Journal Title: Neuron
Volume: 14
Issue: 6
ISSN: 0896-6273
Publisher: Cell Press  
Date Published: 1995-06-01
Start Page: 1141
End Page: 1152
Language: English
DOI: 10.1016/0896-6273(95)90262-7
PUBMED: 7605629
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0029009621&doi=10.1016%2f0896-6273%2895%2990262-7&partnerID=40&md5=7257d694d82e3385ded36b8976c1aacc
Notes: Article -- Export Date: 28 August 2018 -- Source: Scopus
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Eseng Lai
    45 Lai
  2. Vera Soares
    22 Soares
Related MSK Work