Prognostic immune markers in non-small cell lung cancer Journal Article

Authors: Suzuki, K.; Kachala, S. S.; Kadota, K.; Shen, R.; Mo, Q.; Beer, D. G.; Rusch, V. W.; Travis, W. D.; Adusumilli, P. S.
Article Title: Prognostic immune markers in non-small cell lung cancer
Abstract: Tumor-associated immune responses have polarized effects in regulating tumor growth. Although a clear association has been shown between the tumor immune response and clinical outcome in colorectal and ovarian cancers, the role of immune markers for stratifying prognosis in non-small cell lung cancer (NSCLC) is less defined. Herein, we review the prognostic significance of published immune markers in the tumor microenvironment and peripheral blood of NSCLC patients. To identify prognostic immune genes, we reviewed all published gene-profiling studies in NSCLC and delineated the significance of immune genes by doing subanalysis on the microarray database of the NIH Director's Challenge study. This first comprehensive review of prognostic immune markers provides a foundation for further investigating immune responses in NSCLC. ©2011 AACR.
Keywords: cancer survival; gene cluster; overall survival; review; disease free survival; cd3 antigen; transcription factor foxp3; antigen expression; cd8+ t lymphocyte; tumor associated leukocyte; dendritic cell; transforming growth factor beta; lung non small cell cancer; carcinoma, non-small-cell lung; lung neoplasms; interleukin 10; interleukin 8; tumor markers, biological; gene function; gene expression regulation, neoplastic; cd20 antigen; regulatory t lymphocyte; lung adenocarcinoma; cellular immunity; tumor necrosis factor alpha; neutrophil; gamma interferon; blood sampling; microarray analysis; tumor recurrence; cyclooxygenase 2; cd11b antigen; prostaglandin e2; cd4+ t lymphocyte; cytotoxic t lymphocyte; tumor immunity; protein s 100; models, genetic; osteogenic protein 1; macrophage; chemokine receptor ccr7; immune response gene; rho guanine nucleotide binding protein; immunocompetent cell; monocyte chemotactic protein 1; cd14 antigen; suppressor cell; cd33 antigen; inducible nitric oxide synthase; peripheral lymphocyte; tumor microenvironment; gene regulatory networks; chemokine receptor cxcr4; cd15 antigen; models, immunological; secondary lymphoid tissue chemokine; macrophage inflammatory protein 3beta; monocyte chemotactic protein 2; interleukin 7 receptor; cd59 antigen; chemokine receptor ccr6; interleukin 16; triggering receptor expressed on myeloid cells 1
Journal Title: Clinical Cancer Research
Volume: 17
Issue: 16
ISSN: 1078-0432
Publisher: American Association for Cancer Research  
Date Published: 2011-08-15
Start Page: 5247
End Page: 5256
Language: English
DOI: 10.1158/1078-0432.ccr-10-2805
PROVIDER: scopus
PUBMED: 21659461
Notes: --- - "Export Date: 3 October 2011" - "CODEN: CCREF" - "Source: Scopus"
Altmetric Score
MSK Authors
  1. Qianxing Mo
    37 Mo
  2. Valerie W Rusch
    651 Rusch
  3. Ronglai Shen
    127 Shen
  4. William D Travis
    548 Travis
  5. Kei Suzuki
    28 Suzuki
  6. Stefan S Kachala
    10 Kachala
  7. Kyuichi Kadota
    82 Kadota