Identification of GroEL as a constituent of an mRNA‐protection complex in Escherichia coli Journal Article
| Authors: | Georgellis, D.; Sohlberg, B.; Hartl, F. U.; von Gabain, A. |
| Article Title: | Identification of GroEL as a constituent of an mRNA‐protection complex in Escherichia coli |
| Abstract: | An RNA‐binding activity has been identified in Escherichia coli that provides physical protection of RNA against ribonucleases in an ATP‐ and Mg2+‐dependent manner. This binding activity is stimulated under growth conditions known to cause a decrease in the rate of mRNA decay. RNA protection is mediated by a protein complex that contains a modified form of the chaperonin GroEL as an indispensable constituent. These results suggest a new role for GroEL as an RNA chaperone. Copyright © 1995, Wiley Blackwell. All rights reserved |
| Keywords: | nonhuman; protein binding; adenosine diphosphate; rna binding protein; rna-binding proteins; blotting, western; antibodies, monoclonal; messenger rna; rna, messenger; escherichia coli; adenosine triphosphate; protein folding; ribonucleases; rna transcription; protein modification; magnesium ion; ribonuclease; molecular stability; molecular chaperones; cytidine triphosphate; chaperonin 60; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; chaperonin; groel protein; anaerobic growth |
| Journal Title: | Molecular Microbiology |
| Volume: | 16 |
| Issue: | 6 |
| ISSN: | 0950-382X |
| Publisher: | Blackwell Publishing |
| Date Published: | 1995-06-01 |
| Start Page: | 1259 |
| End Page: | 1268 |
| Language: | English |
| DOI: | 10.1111/j.1365-2958.1995.tb02347.x |
| PUBMED: | 8577258 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 28 August 2018 -- Source: Scopus |
