A pilot study of the biologic and therapeutic effects of granulocyte colonystimulating factor (filgrastim) in patients with acute myelogenous leukemia Journal Article

  

Authors:	Jakubowski, A.; Gordon, M.; Tafuri, A.; Schuster, S.; Andreeff, M.; Shieh, J. H.; Vincent, M.; Gabrilove, J.
Article Title:	A pilot study of the biologic and therapeutic effects of granulocyte colonystimulating factor (filgrastim) in patients with acute myelogenous leukemia
Abstract:	In a carefully monitored pilot study, the in vivo biologic effects of filgrastim were investigated in eight patients with relapsed/refractory acute myelogenous leukemia. Within each patient, filgrastim was administered as a single agent prior to any chemotherapy in escalating doses of 0.12-6.0 μg/kg/day as a continuous intravenous infusion. The dose was increased every 14 days until an ANC of ≥2500/mm3 had been achieved or there was evidence of proliferation of the leukemia. In patients who demonstrated growth of the leukemic clone, cytosine arabinoside was initiated at 200 mg/m2/day for 5 days. Throughout the course of therapy, the effects of filgrastim on maturation and proliferation were assessed by in vitro studies of bone marrow aspirates. Three patients demonstrated a sustained increase in ANC; one achieved a partial remission and remained on therapy for 31 weeks. Two of the three responding patients had hypocellular marrows at the time of initiating filgrastim and demonstrated a low but normal pattern of growth in CFU-GM assay early in the treatment course. This suggested that these two characteristics may define an environment in which filgrastim can induce a growth advantage for the normal residual hematopoietic elements. In this study of selected patients, filgrastim appeared safe.
Keywords:	adult; cancer chemotherapy; clinical article; treatment outcome; aged; leukemia; antibiotic agent; acute granulocytic leukemia; human cell; clinical trial; cancer growth; liver dysfunction; cytarabine; cell proliferation; cell differentiation; drug effect; bone marrow biopsy; thrombosis; recombinant granulocyte colony stimulating factor; catheter infection; intravenous drug administration; colony forming unit gm; leukemia remission; g-csf; filgrastim; maturation; human; male; female; priority journal; article
Journal Title:	Leukemia
Volume:	9
Issue:	11
ISSN:	0887-6924
Publisher:	Nature Publishing Group
Date Published:	1995-11-01
Start Page:	1799
End Page:	1804
Language:	English
PUBMED:	7475265
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028844775&partnerID=40&md5=f2ab0dc21a1f68ce11d51fee098c8fd0
Notes:	Article -- Export Date: 28 August 2018 -- Source: Scopus

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