A pilot study of the biologic and therapeutic effects of granulocyte colonystimulating factor (filgrastim) in patients with acute myelogenous leukemia Journal Article


Authors: Jakubowski, A.; Gordon, M.; Tafuri, A.; Schuster, S.; Andreeff, M.; Shieh, J. H.; Vincent, M.; Gabrilove, J.
Article Title: A pilot study of the biologic and therapeutic effects of granulocyte colonystimulating factor (filgrastim) in patients with acute myelogenous leukemia
Abstract: In a carefully monitored pilot study, the in vivo biologic effects of filgrastim were investigated in eight patients with relapsed/refractory acute myelogenous leukemia. Within each patient, filgrastim was administered as a single agent prior to any chemotherapy in escalating doses of 0.12-6.0 μg/kg/day as a continuous intravenous infusion. The dose was increased every 14 days until an ANC of ≥2500/mm3 had been achieved or there was evidence of proliferation of the leukemia. In patients who demonstrated growth of the leukemic clone, cytosine arabinoside was initiated at 200 mg/m2/day for 5 days. Throughout the course of therapy, the effects of filgrastim on maturation and proliferation were assessed by in vitro studies of bone marrow aspirates. Three patients demonstrated a sustained increase in ANC; one achieved a partial remission and remained on therapy for 31 weeks. Two of the three responding patients had hypocellular marrows at the time of initiating filgrastim and demonstrated a low but normal pattern of growth in CFU-GM assay early in the treatment course. This suggested that these two characteristics may define an environment in which filgrastim can induce a growth advantage for the normal residual hematopoietic elements. In this study of selected patients, filgrastim appeared safe.
Keywords: adult; cancer chemotherapy; clinical article; treatment outcome; aged; leukemia; antibiotic agent; acute granulocytic leukemia; human cell; clinical trial; cancer growth; liver dysfunction; cytarabine; cell proliferation; cell differentiation; drug effect; bone marrow biopsy; thrombosis; recombinant granulocyte colony stimulating factor; catheter infection; intravenous drug administration; colony forming unit gm; leukemia remission; g-csf; filgrastim; maturation; human; male; female; priority journal; article
Journal Title: Leukemia
Volume: 9
Issue: 11
ISSN: 0887-6924
Publisher: Nature Publishing Group  
Date Published: 1995-11-01
Start Page: 1799
End Page: 1804
Language: English
PUBMED: 7475265
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 28 August 2018 -- Source: Scopus
Citation Impact
MSK Authors
  1. Jae-Hung Shieh
    76 Shieh
  2. Janice Gabrilove
    115 Gabrilove
  3. Monica W Gordon
    2 Gordon