Effect of enteral and parenteral nutrition on amino acid levels in cancer patients Journal Article
| Authors: | Pearlstone, D. B.; Lee, J. I.; Alexander, R. H.; Chang, T. H.; Brennan, M. F.; Burt, M. |
| Article Title: | Effect of enteral and parenteral nutrition on amino acid levels in cancer patients |
| Abstract: | Background: The syndrome of cancer cachexia can have a significant impact on response to therapy as well as on survival in cancer patients. Therapies directed at metabolic perturbations in cachectic patients are dependent on nutritional repletion and maintenance of adequate amino acid substrate levels. This study compares the ability of oral feeding, enteral nutrition, and total parenteral nutrition to alter plasma amino acid levels in cancer patients. Methods: Patients with esophageal cancer were stratified by weight loss. Patients with < 20% weight loss were randomized to continue an ad libitum oral diet (group I) or to receive total parenteral nutrition (group II) for 2 weeks; patients with > 20% weight loss were randomized to receive either enteral nutrition (group III) or total parenteral nutrition (group IV) for 2 weeks. Plasma amino acid levels were measured before the study and again after 2 weeks of nutrition support. Results: Before therapy, there was no difference between the groups in total or essential amino acid levels; however, patients in all groups had significantly lower total amino acid levels compared with those of normal controls. After 2 weeks of treatment, patients in groups I and III showed no difference in individual, essential, or total amino acid levels. However, patients in groups II and IV showed significant increases in a number of individual amino acids as well as in essential and total amino acid levels after 2 weeks of TPN. Conclusions: Patients with esophageal cancer demonstrated significant alterations in amino acid profiles compared with those of normal controls. Total parenteral nutrition was superior to ad libitum oral feeding and jejunostomy feeding in repleting plasma amino acid levels. (Journal of Parenteral and Enteral Nutrition 19:204-208, 1995). © 1995, Sage Publications. All rights reserved. |
| Keywords: | adult; cancer survival; clinical article; controlled study; aged; middle aged; clinical trial; cancer patient; prospective studies; controlled clinical trial; weight loss; weight reduction; time factors; amino acid blood level; cachexia; amino acids; esophagus cancer; esophageal neoplasms; enteral nutrition; enteric feeding; jejunostomy; parenteral nutrition; nutritional support; parenteral nutrition, total; humans; human; male; female; priority journal; article; amino acids, essential |
| Journal Title: | Journal of Parenteral and Enteral Nutrition |
| Volume: | 19 |
| Issue: | 3 |
| ISSN: | 0148-6071 |
| Publisher: | Sage Publications |
| Date Published: | 1995-05-01 |
| Start Page: | 204 |
| End Page: | 208 |
| Language: | English |
| DOI: | 10.1177/0148607195019003204 |
| PUBMED: | 8551648 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 28 August 2018 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work