Neuropsychiatric syndromes and psychological symptoms in patients with advanced cancer Journal Article


Authors: Breitbart, W.; Bruera, E.; Chochinov, H.; Lynch, M.
Article Title: Neuropsychiatric syndromes and psychological symptoms in patients with advanced cancer
Abstract: This article represents the contributions of the panel on "Neurapsychiatric Syndromes and Psychological Symptoms" of the National Cancer Institute of Canada Workshop on Symptom Control and Supportive Care in Patients with Advanced Cancer. The panel's presentations focused on mood disorders and cognitive disorders, and described the current state of knowledge regarding prevalence, assessment, and intervention. Recommendations for future research are presented based on a consensus of the panel as to the need to fill glaring gaps in our current state of knowledge, and a desire to improve the quality of research in this area of palliative medicine. Recommendations for future research on neuropsychiatric symptoms and syndromes in palliative care include (1) adoption of uniform terminology (taxonomy of disorders) and diagnostic classification systems, (2) utilization of existing validated tools and measures in prevalence and intervention research, (3) development of new tools and measures that are more applicable and relevant to the palliative care setting, (4) encouragement for studies of the prevalence of neuropsychiatric symptoms and syndromes, (5) promotion of intervention studies utilizing pharmacologic and nonpharmacologic treatments for depressive disorders and cognitive disorders in advanced cancer patients, and (6) expansion of the focus of such research to other neuropsychiatric disorders (for example, anxiety disorders, posttraumatic stress disorders, and sleep disorders), symptoms (fatigue and tension) and related issues (suicidal ideation and desire for hastened death). © 1995 United States Cancer Pain Relief Committee.
Keywords: clinical trial; fatigue; advanced cancer; conference paper; cancer patient; neoplasms; palliative care; unindexed drug; chlorpromazine; haloperidol; lorazepam; methylphenidate; midazolam; delirium; extrapyramidal symptom; palliative therapy; depression; syndrome; antidepressant agent; benzodiazepine derivative; neuroleptic agent; distress syndrome; posttraumatic stress disorder; mental disorders; cognitive defect; anxiety; terminal care; cognition disorders; sleep disorder; alprazolam; fluoxetine; paroxetine; sertraline; intravenous drug administration; emotional stress; oral drug administration; tricyclic antidepressant agent; amfebutamone; psychostimulant agent; serotonin uptake inhibitor; intramuscular drug administration; mood disorders; fluvoxamine; suicidal behavior; dexamphetamine; sedative agent; trazodone; nervous system diseases; clomipramine; desipramine; nortriptyline; doxepin; imipramine; tardive dyskinesia; monoamine oxidase inhibitor; subcutaneous drug administration; cognitive disorders; human; psychological symptoms; thioridazine; maprotiline; amoxapine; neuropsychiatric syndromes; moclobemide
Journal Title: Journal of Pain and Symptom Management
Volume: 10
Issue: 2
ISSN: 0885-3924
Publisher: Elsevier Inc.  
Date Published: 1995-02-01
Start Page: 131
End Page: 141
Language: English
DOI: 10.1016/0885-3924(94)00075-v
PUBMED: 7730685
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 28 August 2018 -- Source: Scopus
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  1. William S Breitbart
    346 Breitbart