Conditioned emotional distress in women receiving chemotherapy for breast cancer Journal Article


Authors: Jacobsen, P. B.; Bovbjerg, D. H.; Schwartz, M. D.; Hudis, C. A.; Gilewski, T. A.; Norton, L.
Article Title: Conditioned emotional distress in women receiving chemotherapy for breast cancer
Abstract: This study investigated whether women undergoing outpatient chemotherapy for breast cancer can develop classically conditioned emotional distress. Women scheduled to begin chemotherapy were randomly assigned either to an experimental group (exposed to a distinctive stimulus before each chemotherapy infusion) or a control group. After repeated infusions of chemotherapy, patients' responses to the distinctive stimulus were assessed in a location not associated with chemotherapy administration. At the test trial, experimental group patients showed evidence of increased emotional distress (self-reported on a visual analog scale) after the presentation of the distinctive stimulus, whereas control group patients did not. Post hoc analyses indicated that these increases in distress were not secondary to other conditioned responses (e.g., nausea, taste aversion). Thus, results supported the hypothesis that the pairing of a distinctive stimulus with chemotherapy would result in the development of a conditioned emotional response. © 1995 American Psychological Association.
Keywords: adolescent; adult; cancer chemotherapy; controlled study; middle aged; major clinical study; clinical trial; controlled clinical trial; breast cancer; randomized controlled trial; breast neoplasms; drug therapy; emotions; drinking behavior; emotional stress; conditioning; stimulus response; humans; human; female; article; conditioning (psychology)
Journal Title: Journal of Consulting and Clinical Psychology
Volume: 63
Issue: 1
ISSN: 0022-006X
Publisher: American Psychological Association  
Date Published: 1995-02-01
Start Page: 108
End Page: 114
Language: English
DOI: 10.1037/0022-006x.63.1.108
PUBMED: 7896975
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 28 August 2018 -- Source: Scopus
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  1. Clifford Hudis
    905 Hudis
  2. Larry Norton
    758 Norton