Quantitative studies of monoclonal antibody targeting to disialoganglioside G(D2) in human brain tumors Journal Article
| Authors: | Arbit, E.; Cheung, N. K. V.; Yeh, S. D. J.; Daghighian, F.; Zhang, J. J.; Cordon-Cardo, C.; Pentlow, K.; Canete, A.; Finn, R.; Larson, S. M. |
| Article Title: | Quantitative studies of monoclonal antibody targeting to disialoganglioside G(D2) in human brain tumors |
| Abstract: | Iodine-131 3F8, a murine IgG3 monoclonal antibody that targets to GD2-bearing tumors, was administered intravenously to 12 patients with brain tumors. Six patients received 2 mCi (0.74 Bq) of131I-3F8, five patients 10 mCi (3.7 Bq)/1.73 m2 of131I-3F8, and one patient 2.6 mCi (0.96 Bq) of124I-3F8, with no side-effects. Nine of 11 malignant gliomas and the single metastatic melanoma showed antibody localization, with the best tumor delineation on single-photon emission tomography (SPET) following 10 mCi (3.7 Bq)/1.73 m2 dose. No nonspecific uptake in the normal craniospinal axis was detected. There was no difference in the pharmacokinetics of low-dose versus the higher-dose antibody groups; plasma and total-body half-lives were 18 h and 49 h, respectively. Surgical sampling and time-activity curves based on quantitative imaging showed peak uptake in high-grade glioma at 39 h, with a half-life of 62 h. Tumor uptake at time of surgery averaged 3.5×10-3 %ID/g and peak activity by the conjugate view method averaged 9.2×10-3 %ID/g (3.5-17.8). Mean radiation absorption dose was 3.9 rad per mCi injected (range 0.7-9.6) or 10.5 cGy/Bq (range 1.9-26). There was agreement on positive sites when immunoscintigraphy was compared with technetium-99m glucoheptonate/diethylene triamine penta-acetic acid planar imaging, thallium-201 SPET, and fluorine-18 fluorodeoxyglucose positron emission tomography. Taken together, these data suggest that quantitative estimates of antibody targeting to intracranial tumors can be made using the modified conjugate view method. © 1995 Springer-Verlag. |
| Keywords: | adolescent; adult; child; clinical article; school child; aged; radiation dose; brain tumor; brain neoplasms; melanoma; metastasis; etoposide; carmustine; monoclonal antibody; immunoglobulin g; iodine 131; iodine radioisotopes; glioblastoma; iodine 124; half life time; fluorine 18; single photon emission computer tomography; acetic acid; fluorodeoxyglucose; pharmacokinetics; tomography, emission-computed; organotechnetium compounds; thallium radioisotopes; tomography, emission-computed, single-photon; fluorine radioisotopes; ganglioside; middle age; 3f8; gd2; radioimmunodetection; anaplastic astrocytoma; radiation absorption; deoxyglucose; immunoscintigraphy; fludeoxyglucose f 18; human; male; female; article; support, u.s. gov't, p.h.s.; support, u.s. gov't, non-p.h.s.; gluceptate tc 99m; sugar acids; technetium tc 99m pentetate |
| Journal Title: | European Journal of Nuclear Medicine |
| Volume: | 22 |
| Issue: | 5 |
| ISSN: | 0340-6997 |
| Publisher: | Springer Verlag |
| Date Published: | 1995-05-01 |
| Start Page: | 419 |
| End Page: | 426 |
| Language: | English |
| DOI: | 10.1007/bf00839056 |
| PUBMED: | 7641750 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 28 August 2018 -- Source: Scopus |
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107Yeh -
650Cheung -
279
Finn -
612
Cordon-Cardo -
959Larson -
70
Pentlow -
66
Arbit -
37
Daghighian
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