Efficacy of postoperative 5-FU, high-dose leucovorin, and sequential radiation therapy for clinically resectable rectal cancer Journal Article
| Authors: | Minsky, B. D.; Cohen, A. M.; Enker, W. E.; Kelsen, D. P.; Kemeny, N.; Frankel, J. |
| Article Title: | Efficacy of postoperative 5-FU, high-dose leucovorin, and sequential radiation therapy for clinically resectable rectal cancer |
| Abstract: | We report the local control and survival in a previously reported phase I dose escalation trial of combined postoperative 5-FU, high dose leucovorin (LV), and sequential radiation thercipy followed by maintenance LV15-FU for the treatment of patients with clinically resectable rectal cancer. Following surgery for stages T3-4N0--2M0 primary (21) or recurrent (4) rectal cancer, 25 patients received 5-FU / LV X 1 cycle. Radiation therapy (5040 cGy) began on day 8. A second cycle of.5-FU/LV was given concurrent with the fourth week of radiation Patients received an additional 10 cycles of LV/5-FU. The median follow-up was 40 months (range 18-52). The incidence of grade 3+ acute toxicin, in the 9 patients who received the recommended dose of 5-FU was 44% The local failure rate was 28% Abdominal and distant failure rates were 24% The 3-year actuarial disease-free survival was 74% and the overall survival was 80% Our preliminary data reveal reasonable local control and survival rates. However, further follow-up is needed to assess our results at 5 years. Postoperative combined modality therapy with high-dose LV may be an option for the adjuvant treatment of patients with resectable rectal cancer. © 1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted. |
| Keywords: | adult; clinical article; aged; survival analysis; clinical trial; fluorouracil; diarrhea; combined modality therapy; follow up; adenocarcinoma; leukopenia; antineoplastic combined chemotherapy protocols; folinic acid; phase 1 clinical trial; rectal neoplasms; rectum cancer; leucovorin; intravenous drug administration; middle age; human; male; female; priority journal; article; support, non-u.s. gov't |
| Journal Title: | Cancer Investigation |
| Volume: | 13 |
| Issue: | 1 |
| ISSN: | 0735-7907 |
| Publisher: | Informa Healthcare |
| Date Published: | 1995-01-01 |
| Start Page: | 1 |
| End Page: | 7 |
| Language: | English |
| DOI: | 10.3109/07357909509024888 |
| PUBMED: | 7834464 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 28 August 2018 -- Source: Scopus |
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