Oral combination antiemetics in patients with small cell lung cancer receiving cisplatin or cyclophosphamide plus doxorubicin Journal Article


Authors: Cleri, L. B.; Kris, M. G.; Tyson, L. B.; Pisters, K. M. W.; Clark, R. A.; Gralla, R. J.
Article Title: Oral combination antiemetics in patients with small cell lung cancer receiving cisplatin or cyclophosphamide plus doxorubicin
Abstract: Background. Intravenous antiemetic combinations containing a 5‐HT3 receptor antagonist (like metoclopramide, ondansetron, or granisetron) with dexamethasone have become the standard therapy for the treatment of acute chemotherapy‐induced vomiting. Intravenous antiemetics, however, can be more costly and take more time to prepare and deliver, and therefore are not preferred for home, outpatient, or office use. The objective of this study was to determine the antiemetic activity and safety of the oral combination antiemetic regimen of metoclopramide, dexamethasone, and diphenhydramine in patients with small cell lung cancer receiving standard outpatient chemotherapy programs. Methods. Fifty‐two patients receiving initial cisplatin (60 mg/m2) or cyclophosphamide (600–1500 mg/m2) plus doxorubicin (30–45 mg/m2) received an oral regimen of metoclopramide (3 mg/kg × 2 then 2 mg/kg × 2 or 4 doses), dexamethasone (20 mg) and diphenhydramine (50 mg × 2 or 3 doses) (oral MDD), beginning 30 minutes before chemotherapy. Results. Vomiting was prevented in 15 of 21 (76%) patients (95% confidence interval [CI], 53%–92%) receiving cisplatin and 21 of 31 (71%) individuals (95% CI, 52%–86%) given cyclophosphamide plus doxorubicin. Adverse effects were mild and transient and included sedation, loose stools, akathisia, and hiccoughs. Conclusions. The oral MDD antiemetic regimen prevented acute emesis in 73% of the patients entered and was well tolerated in this population of patients with small cell lung cancer. Copyright © 1995 American Cancer Society
Keywords: adult; cancer surgery; major clinical study; clinical trial; cisplatin; doxorubicin; diarrhea; drug efficacy; nausea; vomiting; antineoplastic combined chemotherapy protocols; carcinoma, non-small-cell lung; lung neoplasms; akathisia; cyclophosphamide; dexamethasone; drug screening; lung small cell cancer; drug therapy, combination; antiemetic agent; antiemetics; somnolence; hiccup; administration, oral; metoclopramide; oral drug administration; diphenhydramine; middle age; human; male; female; priority journal; article; support, non-u.s. gov't
Journal Title: Cancer
Volume: 76
Issue: 5
ISSN: 0008-543X
Publisher: Wiley Blackwell  
Date Published: 1995-09-01
Start Page: 774
End Page: 778
Language: English
DOI: 10.1002/1097-0142(19950901)76:5<774::aid-cncr2820760510>3.0.co;2-5
PUBMED: 8625179
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 28 August 2018 -- Source: Scopus
Altmetric Score
MSK Authors
  1. Mark Kris
    639 Kris
  2. Leslie Tyson
    58 Tyson
  3. Katherine M. W. Pisters
    26 Pisters