Family history of cancer, body weight, and p53 nuclear overexpression in Duke's C colorectal cancer Journal Article


Authors: Zhang, Z. F.; Zeng, Z. S.; Sarkis, A. S.; Klimstra, D. S.; Charytonowicz, E.; Pollack, D.; Vena, J.; Guillem, J.; Marshall, J. R.; Cordon-Cardo, C.; Cohen, A. M.; Begg, C. B.
Article Title: Family history of cancer, body weight, and p53 nuclear overexpression in Duke's C colorectal cancer
Abstract: To examine the hypothesis that colorectal carcinomas with and without TP53 mutations may be characterised by aetiological heterogeneity, we analysed a group of 107 patients with primary Dukes’ C colorectal cancer seen at the Memorial Sloan-Kettering Cancer Center (MSKCC) from 1986 to 1990. We assessed p53 overexpression using the monoclonal antibody PAb 1801, and identified 42 (39%) patients displaying p53-positive phenotype, defined as ≥ or = 25% of positive cells. Patients with two or more first-degree relatives with cancer had an odds ratio (OR) of 2.9 (95% CI 1.0-8.3) for p53 overexpression in comparison with those without a family history of cancer (trend test, P = 0.11). A possible association between body weight and p53 overexpression was observed. The ORs were 1.9 for the second quartile, 1.9 for the third quartile and 3.4 for the highest quartile in comparison with the lowest quartile (trend test, P = 0.06). No association between occupational physical activity, smoking, drinking, parity and p53 overexpression was identified. The results suggest that p53 overexpression may be related to genetic predisposition to colorectal cancer, and p53-positive and p53-negative colorectal cancers may be controlled by different aetiological pathways. © 1995 Stockton Press. All rights reserved.
Keywords: adult; human tissue; aged; gene mutation; major clinical study; cigarette smoking; cancer risk; comparative study; neoplasm staging; colorectal cancer; gene expression; risk factors; body weight; age factors; protein p53; monoclonal antibody; colorectal neoplasms; body mass index; family history; physical activity; cell nucleus; alcohol consumption; genetic predisposition; religion; socioeconomic factors; occupational health; family; genes, p53; hypothesis; middle age; human; male; female; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; racial stocks; p53/protein; blood groups
Journal Title: British Journal of Cancer
Volume: 71
Issue: 4
ISSN: 0007-0920
Publisher: Nature Publishing Group  
Date Published: 1995-04-01
Start Page: 888
End Page: 893
Language: English
DOI: 10.1038/bjc.1995.171
PUBMED: 7710960
PROVIDER: scopus
PMCID: PMC2033726
DOI/URL:
Notes: Source: Scopus
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MSK Authors
  1. Colin B Begg
    239 Begg
  2. Jose Guillem
    373 Guillem
  3. Alfred M Cohen
    175 Cohen
  4. Zhaoshi Zeng
    84 Zeng
  5. David S Klimstra
    852 Klimstra
  6. Zuo-Feng Zhang
    94 Zhang
  7. Alvaro S. Sarkis
    25 Sarkis