Adoptive immunotherapy using donor leukocytes following bone marrow transplantation for chronic myeloid leukemia: Is T cell dose important in determining biological response? Journal Article
| Authors: | Mackinnon, S.; Papadopoulos, E. B.; Carabasi, M. H.; Reich, L.; Collins, N. H.; O'Reilly, R. J. |
| Article Title: | Adoptive immunotherapy using donor leukocytes following bone marrow transplantation for chronic myeloid leukemia: Is T cell dose important in determining biological response? |
| Abstract: | We investigated the use of donor leukocytes for the treatment of Epstein-Barr virus (EBV) lymphoproliferative disease following T cell-depleted bone marrow transplantation (BMT) for chronic myeloid leukemia (CML). We wanted to determine whether donor leukocyte treatment would result in altered biological responses with respect to anti-EBV lymphoma activity, donor-host chimerism and graft-versus-leukemia (GVL) responses. Three patients with CML in cytogenetic remission received < 106/kg donor leukocytes for treatment of EBV lymphoproliferative disease. Lineage specific chimerism and residual leukemia detection were assessed using sensitive PCR methodologies. Following donor leukocyte treatment 1 patient had no recurrence and the other 2 had responsive EBV lymphoma. The 2 patients who were mixed T cell chimeras before treatment, remained so after treatment. Two were BCR-ABL positive by PCR before and after treatment and both developed hematologic relapse. None of the 3 patients developed acute graft-versus-host disease (GVHD) with 1 patient developing limited chronic GVHD. These data suggest that small numbers of donor T cells can eradicate EBV lymphoproliferative disease but may not alter donor-host chimerism or mediate GVL responses. |
| Keywords: | adult; controlled study; human cell; prednisone; case report; methodology; polymerase chain reaction; t lymphocyte; t-lymphocytes; recurrence; cyclophosphamide; steroid; chronic myeloid leukemia; thiotepa; chimera; immunotherapy; graft versus host reaction; remission induction; recurrent disease; lymphoproliferative disease; bone marrow transplantation; adoptive immunotherapy; immunotherapy, adoptive; epstein barr virus; herpesvirus 4, human; oral drug administration; leukemia remission; lymphoproliferative disorders; biological response modifiers; topical drug administration; leukemia, myeloid, chronic; donor leukocytes; human; male; female; priority journal; article; support, u.s. gov't, p.h.s. |
| Journal Title: | Bone Marrow Transplantation |
| Volume: | 15 |
| Issue: | 4 |
| ISSN: | 0268-3369 |
| Publisher: | Nature Publishing Group |
| Date Published: | 1995-04-01 |
| Start Page: | 591 |
| End Page: | 594 |
| Language: | English |
| PUBMED: | 7655386 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
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