Induction of tumor suppressor p21 protein by kinase inhibitors in MCF-7 cells Journal Article

  


Authors: Jeoung, D. I.; Tang, B.; Sonenberg, M.
Article Title: Induction of tumor suppressor p21 protein by kinase inhibitors in MCF-7 cells
Abstract: The expression level of tumor suppressor p21 protein in response to protein kinase inhibitors was examined in MCF-7 cells. Both H7 (serine/threonine kinase inhibitor) and staurosporine (protein kinase C inhibitor) were able to induce p21 protein in a time-and dose-dependent manner. Induction of p21 by H7 but not staurosporine required the induction of p53 protein. Induction of p21 was preceded by the induction of p53 protein. Based on FACS analysis, both H7 and staurosporine act as antimitogenic agents. © 1995 by Academic Press, Inc.
Journal Title: Biochemical and Biophysical Research Communications
Volume: 214
Issue: 2
ISSN: 0006-291X
Publisher: Elsevier Science, Inc.  
Date Published: 1995-09-14
Start Page: 361
End Page: 366
Language: English
DOI: 10.1006/bbrc.1995.2296
PROVIDER: scopus
PUBMED: 7677742
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0029166370&doi=10.1006%2fbbrc.1995.2296&partnerID=40&md5=e7e31582b42ec8185ba1675edef840b2
Notes: Article -- Export Date: 28 August 2018 -- Source: Scopus
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MSK Authors
  1. Baiqing Tang
    14 Tang
  2. Martin Sonenberg
    28 Sonenberg
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