MYC-induced myeloid leukemogenesis is accelerated by all six members of the antiapoptotic BCL family Journal Article
| Authors: | Beverly, L. J.; Varmus, H. E. |
| Article Title: | MYC-induced myeloid leukemogenesis is accelerated by all six members of the antiapoptotic BCL family |
| Abstract: | Signals that control the fine balance between cell death and cell survival are altered during tumorigenesis. Understanding the mechanisms by which this balance is perturbed, leading to excessive cell survival, is important for designing effective therapies. Proteins belonging to the B-cell lymphoma (BCL) family are known to regulate death responses to apoptotic signals, especially those originating within cells. A subset of BCL family members capable of inhibiting cell death is known to contribute to tumorigenesis; however, it is not known whether all six antiapoptotic BCL family members play a causal role in tumor development. Using a mouse model of MYC-driven leukemia, we showed that, in addition to the well characterized BCL2 and BCLxl (BCL2L1), the other four family members - BCLw (BCL2L2), BCLb (BCL2L10), BFL1 (BCL2A1) and MCL1 - also cooperate with MYC to accelerate leukemogenesis. In addition, high levels of each family member are found in either solid human tumors or cell lines derived from human leukemias or lymphomas. © 2009 Macmillan Publishers Limited All rights reserved. |
| Keywords: | controlled study; unclassified drug; oncoprotein; acute granulocytic leukemia; human cell; nonhuman; ki 67 antigen; cell proliferation; mouse; animal tissue; cell death; gene overexpression; protein bcl 2; apoptosis; gene expression; bone marrow; spleen; animal experiment; animal model; protein bcl xl; lung tumor; thymus; colon tumor; bcl2; bclb; bclw; bclxl; bfl1; mcl1; b cell lymphoma protein; bcl2 related protein a1; cd11b antigen; cell surface marker; histone h3; myc protein; protein bcl 10; protein bcl b; protein bcl w; protein gr 1; protein mcl 1; transactivator protein; breast tumor; cancer cell; cancer infiltration; hepatomegaly; leukemia cell; leukemogenesis; liver tumor; lymph node; lymphoma cell; ovary tumor; prostate tumor; splenomegaly; genes, myc; leukemia, myeloid; oncogene proteins |
| Journal Title: | Oncogene |
| Volume: | 28 |
| Issue: | 9 |
| ISSN: | 0950-9232 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2009-03-05 |
| Start Page: | 1274 |
| End Page: | 1279 |
| Language: | English |
| DOI: | 10.1038/onc.2008.466 |
| PUBMED: | 19137012 |
| PROVIDER: | scopus |
| PMCID: | PMC2743088 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 5" - "Export Date: 30 November 2010" - "CODEN: ONCNE" - "Source: Scopus" |
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