Successful treatment of solitary extracranial metastases from non-small cell lung cancer Journal Article
| Authors: | Luketich, J. D.; Martini, N.; Ginsberg, R. J.; Rigberg, D.; Burt, M. E. |
| Article Title: | Successful treatment of solitary extracranial metastases from non-small cell lung cancer |
| Abstract: | Background.: Recurrence after resection of non-small cell lung carcinoma is generally associated with a poor outcome and is treated with either systemic agents or palliative irradiation. Recently, long-term survival has been reported after resection of isolated brain metastases from non-small cell lung carcinoma, but resection of other metastatic sites has not been explored fully. Methods.: We have identified 14 patients who had solitary extracranial metastases treated aggressively after curative treatment of their non-small cell lung carcinoma. The histology was squamous carcinoma in 5, adenocarcinoma in 8, and large cell carcinoma in 1. Initially, 3 patients had stage I, 5 stage II, and 6 stage IIIa disease. Results.: The sites of metastases included extrathoracic lymph nodes (six), skeletal muscle (four), bone (three), and small bowel (one). The median disease-free interval before metastases was 19.5 months (range, 5 to 71 months). Complete surgical resection of the metastatic site was the treatment in 12 of 14 patients. Two patients received only curative irradiation to the metastatic site, with complete response. The overall 10-year actuarial survival (Kaplan-Meier) was 86%. To date, 11 patients are alive and well after treatment of their metastases (17 months to 13 years), 1 has recurrent disease, 1 died of recurrent widespread metastases, and 2 died of unrelated causes. Conclusion.: Long-term survival is possible after treatment of isolated metastases to various sites from non-small cell lung carcinoma, but patient selection is critical. © 1995 The Society of Thoracic Surgeons. |
| Keywords: | survival; adult; clinical article; aged; aged, 80 and over; bone neoplasms; disease-free survival; middle aged; cancer surgery; retrospective studies; squamous cell carcinoma; lymphatic metastasis; adenocarcinoma; metastasis; carcinoma, non-small-cell lung; lung neoplasms; lung cancer; irradiation; recurrent disease; large cell carcinoma; intestinal neoplasms; muscle neoplasms; actuarial analysis; humans; human; male; female; priority journal; article |
| Journal Title: | Annals of Thoracic Surgery |
| Volume: | 60 |
| Issue: | 6 |
| ISSN: | 0003-4975 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 1995-12-01 |
| Start Page: | 1609 |
| End Page: | 1611 |
| Language: | English |
| DOI: | 10.1016/0003-4975(95)00760-1 |
| PUBMED: | 8787451 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 28 August 2018 -- Source: Scopus |
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