Physical and functional cooperation of neural cell adhesion molecule and β1-integrin in neurite outgrowth induction Journal Article
| Authors: | Petridis, A. K.; Nikolopoulos, S. N.; El-Maarouf, A. |
| Article Title: | Physical and functional cooperation of neural cell adhesion molecule and β1-integrin in neurite outgrowth induction |
| Abstract: | Neural cell adhesion molecule (NCAM) and β1-integrin are both involved in cell differentiation, with changes in the expression of these two molecules correlating with changes in the malignancy of tumor cells. There is a known functional correlation between NCAM and β1-integrin in adhesion and also neurite outgrowth in tumor cells. In the present study, we used immunostaining and immunoprecipitation studies to demonstrate that isoform 120 of NCAM associates physically as well as functionally with β1-integrin in the induction of neurite outgrowth in SH-SY5Y-human neuroblastoma cells. The interaction between these two molecules is mandatory for neurite outgrowth. NCAM blockage completely inhibits the effects of β1-integrin on neurite outgrowth. These findings further our understanding of the interactions between NCAMs and integrins in malignancy. © 2011 Elsevier Ltd. All rights reserved. |
| Keywords: | immunohistochemistry; controlled study; human cell; nonhuman; protein function; mouse; protein protein interaction; animal experiment; cell differentiation; neuroblastoma cell; nerve cell adhesion molecule; protein induction; isoprotein; integrins; cell strain; neural cell adhesion molecule; beta1 integrin; cell strain sh sy5y; nerve fiber growth; radioimmunoprecipitation |
| Journal Title: | Journal of Clinical Neuroscience |
| Volume: | 18 |
| Issue: | 8 |
| ISSN: | 0967-5868 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2011-08-01 |
| Start Page: | 1109 |
| End Page: | 1113 |
| Language: | English |
| DOI: | 10.1016/j.jocn.2010.12.047 |
| PROVIDER: | scopus |
| PUBMED: | 21719291 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 3 October 2011" - "CODEN: JCNUE" - "Source: Scopus" |
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