Psychological variables potentially implicated in opioid-related mortality as observed in clinical practice Journal Article


Authors: Passik, S. D.; Lowery, A.
Article Title: Psychological variables potentially implicated in opioid-related mortality as observed in clinical practice
Abstract: Opioid-related deaths in the United States have become a public health problem, with accidental and unintended overdoses being especially troubling. Screening for psychological risk factors is an important first step in safeguarding against nonadherence practices and identifying patients who may be vulnerable to the risks associated with opioid therapy. Validated screening instruments can aid in this attempt as a complementary tool to clinicians' assessments. A structured screening is imperative as part of an assessment, as clinician judgment is not the most reliable method of identifying nonadherence. As a complement to formal screening, we present for discussion and possible future study certain psychological variables observed during years of clinical practice that may be linked to medication nonadherence and accidental overdose. These variables include catastrophizing, fear, impulsivity, attention deficit disorders, existential distress, and certain personality disorders. In our experience, chronic pain patients with dual diagnoses may become "chemical copers" as a way of coping with their negative emotion. For these patients, times of stress could lead to accidental overdose. Behavioral, cognitive-behavioral (acceptance and commitment, dialectical behavior), existential (meaning-centered, dignity), and psychotropic therapies have been effective in treating these high-risk comorbidities, while managing expectations of pain relief appears key to preventing accidental overdose. Wiley Periodicals, Inc.
Keywords: mortality; clinical practice; risk factor; risk assessment; drug fatality; psychological aspect; cognitive therapy; distress syndrome; chronic pain; opioids; fear; behavior therapy; psychotherapy; pain management; aberrant drug-related behavior; drug overdose; attention deficit disorder; accidental overdose; opiate derivative; accident prevention; accidental death; catastrophizing; impulsiveness; personality disorder; preventive health service
Journal Title: Pain Medicine
Volume: 12
Issue: SUPPL. 2
ISSN: 1526-2375
Publisher: Oxford University Press  
Date Published: 2011-06-01
Start Page: S36
End Page: S42
Language: English
DOI: 10.1111/j.1526-4637.2011.01130.x
PROVIDER: scopus
PUBMED: 21668755
PMCID: PMC4112122
DOI/URL:
Notes: --- - "Cited By (since 1996): 2" - "Export Date: 3 October 2011" - "CODEN: PMAEA" - "Source: Scopus"
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  1. Amy E. Lowery-Allison
    14 Lowery