High incidence of thromboembolic events in patients treated with cisplatin-based chemotherapy: A large retrospective analysis Journal Article


Authors: Moore, R. A.; Adel, N.; Riedel, E.; Bhutani, M.; Feldman, D. R.; Tabbara, N. E.; Soff, G.; Parameswaran, R.; Hassoun, H.
Article Title: High incidence of thromboembolic events in patients treated with cisplatin-based chemotherapy: A large retrospective analysis
Abstract: Purpose: This study was designed to determine the incidence of venous and arterial thromboembolic events (TEEs) in patients treated with cisplatin-based chemotherapy and to analyze the prognostic value of patients' baseline and treatment characteristics in predicting TEE occurrence. Patients and Methods: We performed a large retrospective analysis of all patients treated with cisplatin-based chemotherapy for any type of malignancy at Memorial Sloan-Kettering Cancer Center in 2008. A TEE was cisplatin-associated if it occurred between the time of the first dose of cisplatin and 4 weeks after the last dose. Results: Among 932 patients, 169 (18.1%) experienced a TEE during treatment or within 4 weeks of the last dose. TEEs included deep vein thrombosis (DVT) alone in 49.7%, pulmonary embolus (PE) alone in 25.4%, DVT plus PE in 13.6%, arterial TEE alone in 8.3%, or DVT plus arterial TEE in 3.0%. TEEs occurred within 100 days of initiation of treatment in 88% of patients. By univariate analysis, sex, age, race, Karnofsky performance status (KPS), exposure to erythropoiesis-stimulating agents, presence of central venous catheter (CVC), site of cancer, stage of cancer, leukocyte and hemoglobin levels, and Khorana score were all identified as risk factors. However, by multivariate analysis, only age, KPS, presence of CVC, and Khorana score retained significance. Conclusion: This large retrospective analysis confirms the unacceptable incidence of TEEs in patients receiving cisplatin-based chemotherapy. In view of the controversy associated with prophylactic anticoagulation in patients with cancer treated with chemotherapy, randomized studies are urgently needed in this specific cancer population treated with cisplatin-based regimens. © 2011 by American Society of Clinical Oncology.
Journal Title: Journal of Clinical Oncology
Volume: 29
Issue: 25
ISSN: 0732-183X
Publisher: American Society of Clinical Oncology  
Date Published: 2011-09-01
Start Page: 3466
End Page: 3473
Language: English
DOI: 10.1200/jco.2011.35.5669
PROVIDER: scopus
PUBMED: 21810688
DOI/URL:
Notes: --- - "Export Date: 3 October 2011" - "CODEN: JCOND" - "Source: Scopus"
Altmetric Score
MSK Authors
  1. Darren Richard Feldman
    171 Feldman
  2. Hani Hassoun
    146 Hassoun
  3. Gerald A Soff
    59 Soff
  4. Nelly G Adel
    41 Adel
  5. Russell Austin Moore
    3 Moore