Selected biological issues affecting relapse after stem cell transplantation: Role of T-cell impairment, NK cells and intrinsic tumor resistance Journal Article


Authors: van den Brink, M.; Uhrberg, M.; Jahn, L.; DiPersio, J. F.; Pulsipher, M. A.
Article Title: Selected biological issues affecting relapse after stem cell transplantation: Role of T-cell impairment, NK cells and intrinsic tumor resistance
Abstract: The graft vs. leukemia (GvL) effect as a method of preventing relapse is well described after allogeneic hematopoietic cell transplantation (HCT), but the mechanisms to this effect and how tumor sometimes develops resistance to GvL are just beginning to be understood. This article reviews and expands upon data presented at the Third International Workshop on Biology, Prevention and Treatment of Relapse after Stem Cell Transplantation held in Hamburg, Germany, in November 2016. We first discuss in detail the role that T-cell impairment early after HCT plays in relapse by looking at data from T cell-depleted approaches as well as the clear role that early T-cell recovery has shown in improving outcomes. We then review key findings regarding the role of specific KIR donor/recipient pairings that contribute to relapse prevention after HCT for several tumor types. Finally, we discuss a unique mouse model following the development of tumor resistance to GvL. Detailed molecular characterization of events marking the development of tumor resistance to the immunotherapy of GvL may help in developing future strategies to overcome immune escape. © 2018, Macmillan Publishers Limited, part of Springer Nature.
Journal Title: Bone Marrow Transplantation
Volume: 53
Issue: 8
ISSN: 0268-3369
Publisher: Nature Publishing Group  
Date Published: 2018-08-01
Start Page: 949
End Page: 959
Language: English
DOI: 10.1038/s41409-017-0078-0
PROVIDER: scopus
PUBMED: 29367714
DOI/URL:
Notes: Review -- Export Date: 4 September 2018 -- Source: Scopus
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  1. Lorenz Jahn
    6 Jahn