Imaging phenotypes in women at high risk for breast cancer on mammography, ultrasound, and magnetic resonance imaging using the fifth edition of the Breast Imaging Reporting and Data System Journal Article


Authors: Marino, M. A.; Riedl, C. C.; Bernathova, M.; Bernhart, C.; Baltzer, P. A. T.; Helbich, T. H.; Pinker, K.
Article Title: Imaging phenotypes in women at high risk for breast cancer on mammography, ultrasound, and magnetic resonance imaging using the fifth edition of the Breast Imaging Reporting and Data System
Abstract: Objective: To assess imaging phenotypes of familial breast cancer on mammography (MG), ultrasound (US), and magnetic resonance imaging (MRI) using the fifth edition of the BI-RADS; to investigate inter-observer agreement and to correlate imaging phenotypes with risk status, histopathology, and molecular subtypes derived by immunohistochemical surrogate. Materials and Methods: Forty-nine women (BRCA-1/2 mutation carriers and women with >20% lifetime risk) were diagnosed with breast cancer within our high-risk screening program. BI-RADS MG, US, and MRI imaging descriptors were correlated with risk status, histopathology, and molecular subtypes derived by immunohistochemical surrogate. Inter-rater agreement for BI-RADS MG, US, and MRI categories was assessed. Results: Fifty-two breast cancers were diagnosed and 98% were detectable in at least one modality. MRI detected more cancers (P < 0.001). No lesion had benign morphology on BI-RADS. BRCA-1 had triple-negative and high-grade tumors in the posterior part and in the upper-outer quadrant (P ≤ 0.01); positive-family-history patients had intermediate-grade neoplasms (P < 0.01) in the middle part (P = 0.04) and in the upper-outer quadrants (P = 0.05). There was moderate inter-rater agreement for the assigned BI-RADS assessment for MG (k = 0.554) and MRI (k = 0.512) and substantial inter-rater agreement for US (k = 0.741). Conclusions: Imaging phenotypes of familial breast cancers with BI-RADS are malignant in all imaging modalities. Risk status seems to influence cancer location. © 2018 Elsevier B.V.
Keywords: magnetic resonance imaging; breast neoplasms; brca1 protein; brca2 protein; mammography
Journal Title: European Journal of Radiology
Volume: 106
ISSN: 0720-048X
Publisher: Elsevier B.V  
Date Published: 2018-09-01
Start Page: 150
End Page: 159
Language: English
DOI: 10.1016/j.ejrad.2018.07.026
PROVIDER: scopus
PUBMED: 30150038
PMCID: PMC7560944
DOI/URL:
Notes: Article -- Export Date: 4 September 2018 -- Source: Scopus
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  1. Christopher Riedl
    59 Riedl